Description: D-amino-acid oxidase RefSeq Summary (NM_001917): This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg17 chr12:107,776,333-107,797,162 Size: 20,830 Total Exon Count: 11 Strand: + Coding Region Position: hg17 chr12:107,781,249-107,796,777 Size: 15,529 Coding Exon Count: 10
ID:OXDA_HUMAN DESCRIPTION: RecName: Full=D-amino-acid oxidase; Short=DAAO; Short=DAMOX; Short=DAO; EC=1.4.3.3; FUNCTION: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. CATALYTIC ACTIVITY: A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2). COFACTOR: FAD. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.6 mM for D-serine; KM=1.7 mM for D-proline; KM=1.1 mM for D-tyrosine; KM=1.5 mM for D-DOPA; KM=1.2 mM for D-phenylalanine; KM=0.9 mM for D-alanine; SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Peroxisome. SIMILARITY: Belongs to the DAMOX/DASOX family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14920
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006562 proline catabolic process GO:0006625 protein targeting to peroxisome GO:0034641 cellular nitrogen compound metabolic process GO:0036088 D-serine catabolic process GO:0042416 dopamine biosynthetic process GO:0046416 D-amino acid metabolic process GO:0055114 oxidation-reduction process GO:0055130 D-alanine catabolic process GO:0070178 D-serine metabolic process
US Server
