Human Gene HIAT1 (uc001dst.1)
  Description: hippocampus abundant transcript 1
Transcript (Including UTRs)
   Position: hg18 chr1:100,276,377-100,321,517 Size: 45,141 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg18 chr1:100,276,377-100,320,353 Size: 43,977 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:100,276,377-100,321,517)mRNA (may differ from genome)Protein (490 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Hippocampus abundant transcript 1 protein; AltName: Full=Putative tetracycline transporter-like protein;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the major facilitator superfamily.
SEQUENCE CAUTION: Sequence=BAC04836.1; Type=Erroneous initiation; Sequence=BAC11473.1; Type=Erroneous initiation;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

Affymetrix All Exon Microarrays


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -264.821164-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011701 - MFS
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005829 - Sugar_transporter_CS
IPR001958 - Tet-R_TetA/multi-R_MdtG

Pfam Domains:
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q96MC6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity

Biological Process:
GO:0055085 transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK057172 - Homo sapiens cDNA FLJ32610 fis, clone STOMA2000055, highly similar to Mouse mRNA for tetracycline transporter-like protein.
BC156407 - Synthetic construct Homo sapiens clone IMAGE:100061995, MGC:190138 hippocampus abundant transcript 1 (HIAT1) mRNA, encodes complete protein.
BC172469 - Synthetic construct Homo sapiens clone IMAGE:100069163, MGC:199174 hippocampus abundant transcript 1 (HIAT1) mRNA, encodes complete protein.
AF427492 - Homo sapiens putative tetracycline transporter-like protein mRNA, complete cds.
BC073837 - Homo sapiens cDNA clone IMAGE:4480603, **** WARNING: chimeric clone ****.
BC107768 - Homo sapiens hippocampus abundant transcript 1, mRNA (cDNA clone IMAGE:4720459), partial cds.
BC064409 - Homo sapiens hippocampus abundant transcript 1, mRNA (cDNA clone IMAGE:5737455), partial cds.
AK096669 - Homo sapiens cDNA FLJ39350 fis, clone PEBLM2000222, highly similar to Mouse mRNA for tetracycline transporter-like protein.
BC033696 - Homo sapiens hippocampus abundant transcript 1, mRNA (cDNA clone IMAGE:3446672), with apparent retained intron.
AK075208 - Homo sapiens cDNA FLJ90727 fis, clone PLACE1009600, highly similar to Hippocampus abundant gene transcript 1.
AL137576 - Homo sapiens mRNA; cDNA DKFZp564L0864 (from clone DKFZp564L0864).
AK127671 - Homo sapiens cDNA FLJ45769 fis, clone NETRP2002082.
JD370002 - Sequence 351026 from Patent EP1572962.
JD528312 - Sequence 509336 from Patent EP1572962.
JD396863 - Sequence 377887 from Patent EP1572962.
JD313281 - Sequence 294305 from Patent EP1572962.
JD158395 - Sequence 139419 from Patent EP1572962.
JD058573 - Sequence 39597 from Patent EP1572962.
JD067112 - Sequence 48136 from Patent EP1572962.
JD130039 - Sequence 111063 from Patent EP1572962.
LP895149 - Sequence 13 from Patent EP3253886.

-  Other Names for This Gene
  Alternate Gene Symbols: HIAT1_HUMAN, NM_033055, NP_149044, Q6P2N7, Q8N8K2, Q8NBV3, Q96MC6, Q96NY0, Q9NT25
UCSC ID: uc001dst.1
RefSeq Accession: NM_033055
Protein: Q96MC6 (aka HIAT1_HUMAN or HIAT_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_033055.2
exon count: 12CDS single in 3' UTR: no RNA size: 2664
ORF size: 1473CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3014.00frame shift in genome: no % Coverage: 98.99
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.