Human Gene ADCYAP1R1 (uc003tcg.3)
  Description: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), transcript variant 1, mRNA.
RefSeq Summary (NM_001199635): This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr7:31,092,076-31,151,093 Size: 59,018 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr7:31,102,881-31,146,298 Size: 43,418 Coding Exon Count: 16 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:31,092,076-31,151,093)mRNA (may differ from genome)Protein (496 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMalacardsMGIOMIMPubMed
ReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ADCYAP1R1
CDC HuGE Published Literature: ADCYAP1R1
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity , Depressive Disorder, Major , Electrocardiography , Exercise Test , Macular Degeneration , Triglycerides
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    , , . [PubMed 0]
  2. Depressive Disorder, Major
    , , . [PubMed 0]
  3. Depressive Disorder, Major
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: ADCYAP1R1
Diseases sorted by gene-association score: post-traumatic stress disorder (10), anxiety disorder (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.03 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 386.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -144.40289-0.500 Picture PostScript Text
3' UTR -1839.404795-0.384 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain (HRM, Pfam 02793)

ModBase Predicted Comparative 3D Structure on P41586-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK290046 - Homo sapiens cDNA FLJ76767 complete cds, highly similar to Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), mRNA.
AK226138 - Homo sapiens mRNA for type I adenylate cyclase activating polypeptide receptor precursor variant, clone: pf00023.
BC136267 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:167877 IMAGE:9020254), complete cds.
BC117116 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:150725 IMAGE:40125667), complete cds.
BC143679 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:177210 IMAGE:9052193), complete cds.
D17516 - Homo sapiens mRNA for PACAP receptor, complete cds.
E10374 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-A.
E10375 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B.
E10376 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B2.
E10377 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-C.
HQ258442 - Synthetic construct Homo sapiens clone IMAGE:100072871 Unknown protein gene, encodes complete protein.
AY366498 - Homo sapiens pituitary adenyl cyclase activating polypeptide 1 receptor type 1 (ADCYAP1R1) mRNA, complete cds.
AY462278 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY462279 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY495951 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hip variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
AY495952 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I HopII variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
BX538156 - Homo sapiens mRNA; cDNA DKFZp686A0650 (from clone DKFZp686A0650).
AK096545 - Homo sapiens cDNA FLJ39226 fis, clone OCBBF2007232.
JD356047 - Sequence 337071 from Patent EP1572962.
JD378114 - Sequence 359138 from Patent EP1572962.
JD200042 - Sequence 181066 from Patent EP1572962.
JD490579 - Sequence 471603 from Patent EP1572962.
JD466532 - Sequence 447556 from Patent EP1572962.
JD545893 - Sequence 526917 from Patent EP1572962.
JD088716 - Sequence 69740 from Patent EP1572962.
JD330436 - Sequence 311460 from Patent EP1572962.
JD175240 - Sequence 156264 from Patent EP1572962.
JD424643 - Sequence 405667 from Patent EP1572962.
JD448905 - Sequence 429929 from Patent EP1572962.
JD190098 - Sequence 171122 from Patent EP1572962.
JD271204 - Sequence 252228 from Patent EP1572962.
JD536141 - Sequence 517165 from Patent EP1572962.
JD402628 - Sequence 383652 from Patent EP1572962.
JD411584 - Sequence 392608 from Patent EP1572962.
JD264643 - Sequence 245667 from Patent EP1572962.
JD208335 - Sequence 189359 from Patent EP1572962.
JD491112 - Sequence 472136 from Patent EP1572962.
JD490567 - Sequence 471591 from Patent EP1572962.
JD200954 - Sequence 181978 from Patent EP1572962.
AK124304 - Homo sapiens cDNA FLJ42311 fis, clone TRACH2008300.
JD290960 - Sequence 271984 from Patent EP1572962.
JD237444 - Sequence 218468 from Patent EP1572962.
JD545637 - Sequence 526661 from Patent EP1572962.
JD566290 - Sequence 547314 from Patent EP1572962.
JD444097 - Sequence 425121 from Patent EP1572962.
JD213804 - Sequence 194828 from Patent EP1572962.
JD430846 - Sequence 411870 from Patent EP1572962.
JD326333 - Sequence 307357 from Patent EP1572962.
JD492850 - Sequence 473874 from Patent EP1572962.
JD218656 - Sequence 199680 from Patent EP1572962.
JD494711 - Sequence 475735 from Patent EP1572962.
JD453035 - Sequence 434059 from Patent EP1572962.
JD135074 - Sequence 116098 from Patent EP1572962.
JD092677 - Sequence 73701 from Patent EP1572962.
JD243125 - Sequence 224149 from Patent EP1572962.
JD344612 - Sequence 325636 from Patent EP1572962.
JD048611 - Sequence 29635 from Patent EP1572962.
JD369620 - Sequence 350644 from Patent EP1572962.
JD340497 - Sequence 321521 from Patent EP1572962.
JD368967 - Sequence 349991 from Patent EP1572962.
JD263090 - Sequence 244114 from Patent EP1572962.
JD293792 - Sequence 274816 from Patent EP1572962.
JD536838 - Sequence 517862 from Patent EP1572962.
JD524118 - Sequence 505142 from Patent EP1572962.
JD206361 - Sequence 187385 from Patent EP1572962.
JD231824 - Sequence 212848 from Patent EP1572962.
JD247863 - Sequence 228887 from Patent EP1572962.
JD444530 - Sequence 425554 from Patent EP1572962.
JD137293 - Sequence 118317 from Patent EP1572962.
JD162502 - Sequence 143526 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

BioCyc Knowledge Library
PWY3DJ-1 - cyclic AMP biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein P41586 (Reactome details) participates in the following event(s):

R-HSA-187678 TRKA activation by PACAP type 1 receptor
R-HSA-420131 The PACAP receptor binds PACAP
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-187024 NGF-independant TRKA activation
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-187015 Activation of TRKA receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-166520 Signaling by NTRKs
R-HSA-372790 Signaling by GPCR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001199635, NP_001186564, P41586-2
UCSC ID: uc003tcg.3
RefSeq Accession: NM_001199635
Protein: P41586-2, splice isoform of P41586 CCDS: CCDS56480.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199635.1
exon count: 17CDS single in 3' UTR: no RNA size: 6593
ORF size: 1491CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3074.00frame shift in genome: no % Coverage: 99.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.