Human Gene AGAP3 (uc003wjg.1)
  Description: Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 (AGAP3), transcript variant 1, mRNA.
RefSeq Summary (NM_031946): This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017].
Transcript (Including UTRs)
   Position: hg19 chr7:150,783,826-150,841,523 Size: 57,698 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr7:150,783,829-150,841,030 Size: 57,202 Coding Exon Count: 18 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:150,783,826-150,841,523)mRNA (may differ from genome)Protein (911 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): AGAP3
CDC HuGE Published Literature: AGAP3
Positive Disease Associations: Body Mass Index
Related Studies:
  1. Body Mass Index
    , , . [PubMed 0]
  2. Body Mass Index
    , , . [PubMed 0]
  3. Body Mass Index
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 63.86 RPKM in Brain - Cortex
Total median expression: 1045.23 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -194.30493-0.394 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00071 - Ras family
PF01412 - Putative GTPase activating protein for Arf
PF12796 - Ankyrin repeats (3 copies)

SCOP Domains:
50729 - PH domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat
57863 - Pyk2-associated protein beta ARF-GAP domain

ModBase Predicted Comparative 3D Structure on Q96P47-4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AK055393 - Homo sapiens cDNA FLJ30831 fis, clone FEBRA2001989, highly similar to Centaurin-gamma 3.
AF359283 - Homo sapiens MRIP-1 mRNA, complete cds.
BC069236 - Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, mRNA (cDNA clone IMAGE:4876287).
AF413079 - Homo sapiens centaurin gamma3 mRNA, complete cds.
AB209781 - Homo sapiens mRNA for centaurin, gamma 3 variant protein.
BC044644 - Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, mRNA (cDNA clone MGC:52327 IMAGE:5453989), complete cds.
EU831533 - Synthetic construct Homo sapiens clone HAIB:100066562; DKFZo004D0518 centaurin, gamma 3 protein (CENTG3) gene, encodes complete protein.
EU831441 - Synthetic construct Homo sapiens clone HAIB:100066470; DKFZo008D0517 centaurin, gamma 3 protein (CENTG3) gene, encodes complete protein.
BC020426 - Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, mRNA (cDNA clone IMAGE:3857278).
AK096352 - Homo sapiens cDNA FLJ39033 fis, clone NT2RP7007842, weakly similar to Drosophila melanogaster Centaurin Gamma 1A (ceng1A) mRNA.
AK131236 - Homo sapiens cDNA FLJ16146 fis, clone BRAMY2040159, highly similar to Homo sapiens MRIP-1 mRNA.
BC048300 - Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, mRNA (cDNA clone IMAGE:5517750), partial cds.
BC037543 - Homo sapiens, Similar to centaurin, gamma 3, clone IMAGE:5183789, mRNA.
AK027415 - Homo sapiens cDNA FLJ14509 fis, clone NT2RM1000499, weakly similar to Caenorhabditis elegans mRNA for centaurin gamma 1A.
AL442089 - Homo sapiens mRNA; cDNA DKFZp761E2216 (from clone DKFZp761E2216).
JD130653 - Sequence 111677 from Patent EP1572962.
JD509608 - Sequence 490632 from Patent EP1572962.
JD445631 - Sequence 426655 from Patent EP1572962.
JD379421 - Sequence 360445 from Patent EP1572962.
JD185729 - Sequence 166753 from Patent EP1572962.
JD316704 - Sequence 297728 from Patent EP1572962.
JD205157 - Sequence 186181 from Patent EP1572962.
JD444456 - Sequence 425480 from Patent EP1572962.
JD343492 - Sequence 324516 from Patent EP1572962.
JD525564 - Sequence 506588 from Patent EP1572962.
JD130925 - Sequence 111949 from Patent EP1572962.
JD141959 - Sequence 122983 from Patent EP1572962.
JD158340 - Sequence 139364 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CENTG3, NM_031946, NP_114152, Q96P47-4
UCSC ID: uc003wjg.1
RefSeq Accession: NM_031946
Protein: Q96P47-4, splice isoform of Q96P47 CCDS: CCDS43681.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_031946.4
exon count: 18CDS single in 3' UTR: no RNA size: 3247
ORF size: 2736CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5394.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.