Description: Homo sapiens angiotensin II receptor-associated protein (AGTRAP), transcript variant 1, mRNA. RefSeq Summary (NM_020350): This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:11,796,142-11,810,828 Size: 14,687 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr1:11,796,266-11,810,249 Size: 13,984 Coding Exon Count: 5
ID:ATRAP_HUMAN DESCRIPTION: RecName: Full=Type-1 angiotensin II receptor-associated protein; AltName: Full=AT1 receptor-associated protein; FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. SUBUNIT: Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1. INTERACTION: Q96AL5:PBX3; NbExp=3; IntAct=EBI-741181, EBI-741171; Q9UKF7:PITPNC1; NbExp=3; IntAct=EBI-741181, EBI-749241; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. SEQUENCE CAUTION: Sequence=CAI15876.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/agtrap/";
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06396 - Angiotensin II, type I receptor-associated protein (AGTRAP)
ModBase Predicted Comparative 3D Structure on Q6RW13
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.