Human Gene ARMC10 (uc003vaw.2)
  Description: Homo sapiens armadillo repeat containing 10 (ARMC10), transcript variant A, mRNA.
RefSeq Summary (NM_031905): This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011].
Transcript (Including UTRs)
   Position: hg19 chr7:102,715,328-102,740,210 Size: 24,883 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr7:102,715,720-102,739,000 Size: 23,281 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:102,715,328-102,740,210)mRNA (may differ from genome)Protein (343 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer
GeneCardsGeneNetworkH-INVHGNCHPRDLynx
MGIneXtProtOMIMPubMedTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ARM10_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 10; AltName: Full=Splicing variant involved in hepatocarcinogenesis protein;
FUNCTION: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.
SUBUNIT: Interacts with the DNA-binding domain of p53/TP53.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.
MISCELLANEOUS: Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
SIMILARITY: Contains 1 ARM repeat.
SEQUENCE CAUTION: Sequence=AAS07482.1; Type=Erroneous gene model prediction;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ARMC10
CDC HuGE Published Literature: ARMC10

-  MalaCards Disease Associations
  MalaCards Gene Search: ARMC10
Diseases sorted by gene-association score: lateral medullary syndrome (2), cloacogenic carcinoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.90 RPKM in Cervix - Endocervix
Total median expression: 586.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -207.20392-0.529 Picture PostScript Text
3' UTR -325.451210-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR006911 - ARM-rpt_dom
IPR016024 - ARM-type_fold

Pfam Domains:
PF04826 - Armadillo-like

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q8N2F6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002039 p53 binding
GO:0050692 DBD domain binding

Biological Process:
GO:0040008 regulation of growth
GO:0040010 positive regulation of growth rate
GO:0043066 negative regulation of apoptotic process
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component:
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY150852 - Homo sapiens SVH-C (SVH) mRNA, complete cds; alternatively spliced.
AY150851 - Homo sapiens SVH-D (SVH) mRNA, complete cds; alternatively spliced.
AY150853 - Homo sapiens SVH-B (SVH) mRNA, complete cds; alternatively spliced.
AY150854 - Homo sapiens SVH-A (SVH) mRNA, complete cds; alternatively spliced.
JD125947 - Sequence 106971 from Patent EP1572962.
JD151848 - Sequence 132872 from Patent EP1572962.
JD395342 - Sequence 376366 from Patent EP1572962.
JD408073 - Sequence 389097 from Patent EP1572962.
JD203583 - Sequence 184607 from Patent EP1572962.
JD202195 - Sequence 183219 from Patent EP1572962.
JD532579 - Sequence 513603 from Patent EP1572962.
JD459371 - Sequence 440395 from Patent EP1572962.
JD120239 - Sequence 101263 from Patent EP1572962.
AK075500 - Homo sapiens cDNA PSEC0198 fis, clone HEMBA1001552, highly similar to SVH protein.
JD289974 - Sequence 270998 from Patent EP1572962.
AK301565 - Homo sapiens cDNA FLJ58864 complete cds, highly similar to Homo sapiens SVH protein (SVH), mRNA.
AK225082 - Homo sapiens mRNA for SVH protein variant, clone: CAS03134.
AK291818 - Homo sapiens cDNA FLJ77334 complete cds, highly similar to Homo sapiens SVH protein, mRNA.
JD384528 - Sequence 365552 from Patent EP1572962.
BC003586 - Homo sapiens armadillo repeat containing 10, mRNA (cDNA clone MGC:3195 IMAGE:3357276), complete cds.
JD460406 - Sequence 441430 from Patent EP1572962.
JD462754 - Sequence 443778 from Patent EP1572962.
KJ899721 - Synthetic construct Homo sapiens clone ccsbBroadEn_09115 ARMC10 gene, encodes complete protein.
AF275808 - Homo sapiens PNAS-112 mRNA, partial sequence.
AK095169 - Homo sapiens cDNA FLJ37850 fis, clone BRSSN2013733, weakly similar to Homo sapiens mRNA for ALEX1.
JD046742 - Sequence 27766 from Patent EP1572962.
JD245264 - Sequence 226288 from Patent EP1572962.
JD394090 - Sequence 375114 from Patent EP1572962.
JD564968 - Sequence 545992 from Patent EP1572962.
JD512383 - Sequence 493407 from Patent EP1572962.
JD237155 - Sequence 218179 from Patent EP1572962.
JD099750 - Sequence 80774 from Patent EP1572962.
JD359603 - Sequence 340627 from Patent EP1572962.
JD425772 - Sequence 406796 from Patent EP1572962.
JD278279 - Sequence 259303 from Patent EP1572962.
JD498527 - Sequence 479551 from Patent EP1572962.
JD478389 - Sequence 459413 from Patent EP1572962.
JD140156 - Sequence 121180 from Patent EP1572962.
JD142585 - Sequence 123609 from Patent EP1572962.
JD347050 - Sequence 328074 from Patent EP1572962.
JD376122 - Sequence 357146 from Patent EP1572962.
JD497908 - Sequence 478932 from Patent EP1572962.
JD110558 - Sequence 91582 from Patent EP1572962.
JD536211 - Sequence 517235 from Patent EP1572962.
JD421679 - Sequence 402703 from Patent EP1572962.
JD180005 - Sequence 161029 from Patent EP1572962.
JD206484 - Sequence 187508 from Patent EP1572962.
JD438924 - Sequence 419948 from Patent EP1572962.
JD319325 - Sequence 300349 from Patent EP1572962.
JD310372 - Sequence 291396 from Patent EP1572962.
JD447189 - Sequence 428213 from Patent EP1572962.
JD447268 - Sequence 428292 from Patent EP1572962.
JD531387 - Sequence 512411 from Patent EP1572962.
JD531388 - Sequence 512412 from Patent EP1572962.
JD138137 - Sequence 119161 from Patent EP1572962.
JD175517 - Sequence 156541 from Patent EP1572962.
JD175516 - Sequence 156540 from Patent EP1572962.
JD540669 - Sequence 521693 from Patent EP1572962.
JD359947 - Sequence 340971 from Patent EP1572962.
JD549151 - Sequence 530175 from Patent EP1572962.
JD048749 - Sequence 29773 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K703, ARM10_HUMAN, B4DWJ8, NM_031905, NP_114111, PSEC0198, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q8N2F6, Q9BTM6, SVH
UCSC ID: uc003vaw.2
RefSeq Accession: NM_031905
Protein: Q8N2F6 (aka ARM10_HUMAN)
CCDS: CCDS5728.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_031905.4
exon count: 7CDS single in 3' UTR: no RNA size: 2651
ORF size: 1032CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2078.00frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.