Description: Homo sapiens autophagy related 7 (ATG7), transcript variant 1, mRNA. RefSeq Summary (NM_006395): This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr3:11,314,010-11,599,139 Size: 285,130 Total Exon Count: 19 Strand: + Coding Region Position: hg19 chr3:11,340,170-11,596,317 Size: 256,148 Coding Exon Count: 18
ID:ATG7_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7; AltName: Full=ATG12-activating enzyme E1 ATG7; AltName: Full=Autophagy-related protein 7; Short=APG7-like; Short=hAGP7; AltName: Full=Ubiquitin-activating enzyme E1-like protein; FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. INTERACTION: P29692:EEF1D; NbExp=2; IntAct=EBI-987834, EBI-358607; O95166:GABARAP; NbExp=8; IntAct=EBI-987834, EBI-712001; Q9H0R8:GABARAPL1; NbExp=6; IntAct=EBI-987834, EBI-746969; P60520:GABARAPL2; NbExp=4; IntAct=EBI-987834, EBI-720116; P14316:IRF2; NbExp=2; IntAct=EBI-987834, EBI-2866589; Q9GZQ8:MAP1LC3B; NbExp=7; IntAct=EBI-987834, EBI-373144; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity). SIMILARITY: Belongs to the ATG7 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ATG7 CDC HuGE Published Literature: ATG7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 69572 - Activating enzymes of the ubiquitin-like proteins 51735 - NAD(P)-binding Rossmann-fold domains
ModBase Predicted Comparative 3D Structure on O95352
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.