Human Gene BRAF (uc003vwc.4) Description and Page Index
  Description: Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.
RefSeq Summary (NM_004333): This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M95712.2, BC101757.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: hg19 chr7:140,433,813-140,624,564 Size: 190,752 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr7:140,434,397-140,624,503 Size: 190,107 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:140,433,813-140,624,564)mRNA (may differ from genome)Protein (766 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: BRAF_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase B-raf; EC=2.7.11.1; AltName: Full=Proto-oncogene B-Raf; AltName: Full=p94; AltName: Full=v-Raf murine sarcoma viral oncogene homolog B1;
FUNCTION: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
ENZYME REGULATION: Activity is increased by EGF and HGF.
SUBUNIT: Monomer. Homodimer. Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr- 753. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with DGKH. Interacts with PRMT5.
INTERACTION: P04049:RAF1; NbExp=30; IntAct=EBI-365980, EBI-365996;
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm. Cell membrane (By similarity). Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes (By similarity).
TISSUE SPECIFICITY: Brain and testis.
PTM: Phosphorylation at Ser-365 by SGK1 inhibits its activity.
PTM: Methylation at Arg-671 decreases stability and kinase activity.
PTM: Ubiquitinated by RNF149; which leads to proteasomal degradation.
DISEASE: Note=Defects in BRAF are found in a wide range of cancers.
DISEASE: Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].
DISEASE: Defects in BRAF are involved in lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
DISEASE: Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
DISEASE: Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
DISEASE: Defects in BRAF are the cause of Noonan syndrome type 7 (NS7) [MIM:613706]. Noonan syndrome is a disorder characterized by facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable intellectual deficits.
DISEASE: Defects in BRAF are the cause of LEOPARD syndrome type 3 (LEOPARD3) [MIM:613707]. LEOPARD3 is a disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.
DISEASE: Note=A chromosomal aberration involving BRAF is found in pilocytic astrocytomas. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 RBD (Ras-binding) domain.
SEQUENCE CAUTION: Sequence=AAD43193.1; Type=Erroneous gene model prediction; Sequence=CAQ43111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43112.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43113.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BRAFID828.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/BRAF";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BRAF
CDC HuGE Published Literature: BRAF
Positive Disease Associations: Body Height , colorectal cancer , Frontal Lobe , melanoma , melanoma|Skin Neoplasms , thyroid cancer , Vitamin E
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Body Height
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: BRAF
Diseases sorted by gene-association score: cardiofaciocutaneous syndrome* (1601), lung cancer* (1278), noonan syndrome 7* (1229), colorectal cancer* (992), leopard syndrome 3* (829), braf-related noonan syndrome* (500), noonan syndrome 1* (385), hashimoto-pritzker syndrome* (350), classic hairy cell leukemia* (350), melanoma* (323), craniopharyngioma* (253), cardiomyopathy, hypertrophic, 4* (231), ptpn11-related noonan syndrome* (231), pilocytic astrocytoma* (208), colonic benign neoplasm* (200), noonan syndrome with multiple lentigines* (175), lymphoma, non-hodgkin* (122), thyroid carcinoma somatic* (117), braf-related cardiofaciocutaneous syndrome* (100), braf-related leopard syndrome* (100), differentiated thyroid carcinoma* (88), adenocarcinoma (68), malignant melanoma, somatic* (45), thyroid cancer (35), spitz nevus (25), erdheim-chester disease (25), hodgkin lymphoma (25), sarcoma (24), hairy cell leukemia (22), thyroid cancer, nonmedullary, 1 (19), leopard syndrome (19), desmoplastic infantile astrocytoma/ganglioglioma (19), desmoplastic infantile astrocytoma (18), syringocystadenoma papilliferum (18), refractory hairy cell leukemia (18), myopericytoma (18), thyroid cancer, anaplastic (14), colorectal adenocarcinoma (14), pulmonic stenosis (13), papillary carcinoma (13), papillary craniopharyngioma (13), nevus of ota (13), granulomatous dermatitis (13), nephrotic syndrome, type 3 (13), metanephric adenoma (11), rhabdoid meningioma (10), pleomorphic xanthoastrocytoma (10), struma ovarii (9), lynch syndrome (9), adenofibroma (9), histiocytosis (8), adenoma (8), skin melanoma (8), hyperplastic polyposis syndrome (8), small intestinal adenocarcinoma (8), mature teratoma (8), pilocytic astrocytoma of cerebellum (8), mucosal melanoma (8), ganglioglioma (8), papillary tumor of the pineal region (7), juvenile myelomonocytic leukemia (7), lip cancer (7), amelanotic melanoma (7), cerebellar astrocytoma (7), uveal melanoma (6), villous adenoma (6), lymphoma (6), histiocytic sarcoma (6), nodular goiter (6), hereditary colorectal cancer (5), thyroid cancer, nonmedullary, 2 (5), letterer-siwe disease (5), familial colorectal cancer (5), giant cell glioblastoma (4), endometrial cancer (3), renal cell carcinoma (2), lung cancer susceptibility 3 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C471405 sorafenib
  • D000082 Acetaminophen
  • D000242 Cyclic AMP
  • C551177 PLX4032
  • D010634 Phenobarbital
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C078765 2,3,5-(triglutathion-S-yl)hydroquinone
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.20 RPKM in Testis
Total median expression: 148.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.6061-0.256 Picture PostScript Text
3' UTR -133.92584-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020454 - DAG/PE-bd
IPR011009 - Kinase-like_dom
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR003116 - Raf-like_ras-bd
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF00130 - Phorbol esters/diacylglycerol binding domain (C1 domain)
PF02196 - Raf-like Ras-binding domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)
54236 - Ubiquitin-like
57889 - Cysteine-rich domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1UWH
- X-ray MuPIT

1UWJ
- X-ray MuPIT

2FB8
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2L05 - NMR MuPIT 3C4C - X-ray MuPIT 3D4Q - X-ray MuPIT
3IDP - X-ray MuPIT 3II5 - X-ray MuPIT 3NY5 - X-ray MuPIT
3OG7 - X-ray MuPIT 3PPJ - X-ray MuPIT 3PPK - X-ray MuPIT
3PRF - X-ray MuPIT 3PRI - X-ray MuPIT 3PSB - X-ray MuPIT
3PSD - X-ray MuPIT 3Q4C - X-ray MuPIT 3Q96 - X-ray MuPIT
3SKC - X-ray MuPIT 3TV4 - X-ray MuPIT 3TV6 - X-ray MuPIT
4DBN - X-ray MuPIT 4E26 - X-ray MuPIT 4E4X - X-ray MuPIT
4FK3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P15056
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0031267 small GTPase binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0009887 animal organ morphogenesis
GO:0009968 negative regulation of signal transduction
GO:0010628 positive regulation of gene expression
GO:0010828 positive regulation of glucose transport
GO:0016310 phosphorylation
GO:0030154 cell differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  M95712 - Homo sapiens B-raf protein (BRAF) mRNA, complete cds.
BC101757 - Homo sapiens v-raf murine sarcoma viral oncogene homolog B1, mRNA (cDNA clone MGC:126806 IMAGE:8069263), complete cds.
BC112079 - Homo sapiens v-raf murine sarcoma viral oncogene homolog B1, mRNA (cDNA clone MGC:138284 IMAGE:8327547), complete cds.
AK314346 - Homo sapiens cDNA, FLJ95109.
KJ890780 - Synthetic construct Homo sapiens clone ccsbBroadEn_00174 BRAF gene, encodes complete protein.
KR712180 - Synthetic construct Homo sapiens clone CCSBHm_00036663 BRAF (BRAF) mRNA, encodes complete protein.
AB529216 - Synthetic construct DNA, clone: pF1KB5776, Homo sapiens BRAF gene for v-raf murine sarcoma viral oncogene homolog B1, without stop codon, in Flexi system.
GU149303 - Homo sapiens SLC45A3-BRAF fusion protein mRNA, complete cds.
HM053972 - Homo sapiens AGTRAP-BRAF fusion protein mRNA, complete cds.
BC038966 - Homo sapiens, Similar to v-raf murine sarcoma viral oncogene homolog B1, clone IMAGE:4391530, mRNA.
JD168570 - Sequence 149594 from Patent EP1572962.
M21001 - Human B-raf oncogene mRNA, 3' end.
LP057483 - Sequence 1 from Patent EP2841598.
LP057484 - Sequence 2 from Patent EP2841598.
LP057523 - Sequence 41 from Patent EP2841598.
LP057524 - Sequence 42 from Patent EP2841598.
HM437233 - Homo sapiens serine/threonine-protein kinase B-raf variant (BRAF) mRNA, partial cds.
JD560335 - Sequence 541359 from Patent EP1572962.
DJ444894 - Combinatorial Methods and Compositions for Treatment of Melanoma.
AK054801 - Homo sapiens cDNA FLJ30239 fis, clone BRACE2002081, weakly similar to B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE.
JD019544 - Sequence 568 from Patent EP1572962.
JD032247 - Sequence 13271 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04150 - mTOR signaling pathway
hsa04270 - Vascular smooth muscle contraction
hsa04510 - Focal adhesion
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04730 - Long-term depression
hsa04810 - Regulation of actin cytoskeleton
hsa04910 - Insulin signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05216 - Thyroid cancer
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05223 - Non-small cell lung cancer

Reactome (by CSHL, EBI, and GO)

Protein P15056 (Reactome details) participates in the following event(s):

R-HSA-1295604 B-RAF dissociates from S111/S120 p-SPRY2
R-HSA-5675198 Activated MAPKs phosphorylate BRAF
R-HSA-169901 (ARMS)Rap1-GTP binds and activates B-Raf
R-HSA-187698 RIT/RIN-GTP binds B-RAF
R-HSA-170965 (Frs2)Rap1-GTP binds to and activates B-Raf
R-HSA-442726 Raf activation
R-HSA-5672951 Inactive RAFs bind YWHAB
R-HSA-5674140 PAQR3 binds inactive RAFs
R-HSA-5672960 YWHAB dimer dissociates from dephosphorylated RAF
R-HSA-5672966 RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs
R-HSA-6802938 Inhibitors bind and inhibit highly active BRAF mutants
R-HSA-6803227 Dissociation of high activity BRAF complexes
R-HSA-6802915 Moderate kinase activity BRAF mutants bind RAS:GTP
R-HSA-6802930 Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance
R-HSA-6802937 Inactive BRAF mutants bind mutant RAS:GTP
R-HSA-5672961 PP2A dephosphorylates inactive RAFs
R-HSA-6802908 RAS mutants bind inactive RAF
R-HSA-5672950 "Activator" RAF:YWHAB dimer binds RAS:GTP
R-HSA-5672980 Dissociation of RAS:RAF complex
R-HSA-5675431 PP2A dephosphorylates RAF1
R-HSA-5675417 PEBP1 binds activated RAF1
R-HSA-5675433 PP5 dephosphorylates RAF1 S338
R-HSA-5672969 Phosphorylation of RAF
R-HSA-5674132 WDR83:LAMTOR2:LAMTOR3 binds MAPK components
R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex
R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks
R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
R-HSA-8936676 Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6803230 Dissociation of moderate activity BRAF complexes
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes
R-HSA-8936731 Inactive BRAF mutants:mutant RAS:GTP bind RAF1
R-HSA-5672978 RAF phosphorylates MAP2K dimer
R-HSA-5672973 MAP2Ks phosphorylate MAPKs
R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex
R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-5674499 Negative feedback regulation of MAPK pathway
R-HSA-170984 ARMS-mediated activation
R-HSA-187706 Signalling to p38 via RIT and RIN
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-170968 Frs2-mediated activation
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-5673000 RAF activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-169893 Prolonged ERK activation events
R-HSA-187687 Signalling to ERKs
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-438064 Post NMDA receptor activation events
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802949 Signaling by RAS mutants
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-190236 Signaling by FGFR
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-5683057 MAPK family signaling cascades
R-HSA-1643685 Disease
R-HSA-162582 Signal Transduction
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: A4D1T4, B6HY61, B6HY62, B6HY63, B6HY64, B6HY65, B6HY66, BRAF1, BRAF_HUMAN, NM_004333, NP_004324, P15056, Q13878, Q3MIN6, Q9UDP8, Q9Y6T3, RAFB1
UCSC ID: uc003vwc.4
RefSeq Accession: NM_004333
Protein: P15056 (aka BRAF_HUMAN)
CCDS: CCDS5863.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene BRAF:
cfc (Cardiofaciocutaneous Syndrome)
leopard (Noonan Syndrome with Multiple Lentigines)
noonan (Noonan Syndrome)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004333.4
exon count: 18CDS single in 3' UTR: no RNA size: 2949
ORF size: 2301CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4528.00frame shift in genome: no % Coverage: 99.90
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.