Human Gene CDC27 (uc002ile.4)
  Description: Homo sapiens cell division cycle 27 (CDC27), transcript variant 1, mRNA.
RefSeq Summary (NM_001114091): The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014].
Transcript (Including UTRs)
   Position: hg19 chr17:45,195,311-45,266,665 Size: 71,355 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr17:45,198,301-45,266,538 Size: 68,238 Coding Exon Count: 19 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:45,195,311-45,266,665)mRNA (may differ from genome)Protein (830 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDC27
CDC HuGE Published Literature: CDC27

-  MalaCards Disease Associations
  MalaCards Gene Search: CDC27
Diseases sorted by gene-association score: cervix carcinoma (3), breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D015655 1-Methyl-4-phenylpyridinium
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D000643 Ammonium Chloride
  • D001564 Benzo(a)pyrene
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.09 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 425.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.80127-0.447 Picture PostScript Text
3' UTR -785.382990-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026803 - CDC27
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF00515 - Tetratricopeptide repeat
PF07719 - Tetratricopeptide repeat
PF12895 - Anaphase-promoting complex, cyclosome, subunit 3
PF13174 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13414 - TPR repeat
PF13432 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on G3V1C4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD FlyBase  
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Descriptions from all associated GenBank mRNAs
  LF384810 - JP 2014500723-A/192313: Polycomb-Associated Non-Coding RNAs.
S78234 - nuc2 homolog [human, fibroblasts, mRNA, 3320 nt].
BC011656 - Homo sapiens cell division cycle 27 homolog (S. cerevisiae), mRNA (cDNA clone MGC:12709 IMAGE:4301175), complete cds.
AK296881 - Homo sapiens cDNA FLJ57525 complete cds, highly similar to Cell division cycle protein 27 homolog.
U00001 - Human homologue of S. pombe nuc2+ and A. nidulans bimA.
KJ896579 - Synthetic construct Homo sapiens clone ccsbBroadEn_05973 CDC27 gene, encodes complete protein.
DQ892780 - Synthetic construct clone IMAGE:100005410; FLH189657.01X; RZPDo839H0774D cell division cycle 27 (CDC27) gene, encodes complete protein.
DQ896027 - Synthetic construct Homo sapiens clone IMAGE:100010487; FLH189653.01L; RZPDo839H0764D cell division cycle 27 (CDC27) gene, encodes complete protein.
AB384784 - Synthetic construct DNA, clone: pF1KB3312, Homo sapiens CDC27 gene for cell division cycle protein 27 homolog, complete cds, without stop codon, in Flexi system.
AK299342 - Homo sapiens cDNA FLJ56539 complete cds, highly similar to Cell division cycle protein 27 homolog.
MA620387 - JP 2018138019-A/192313: Polycomb-Associated Non-Coding RNAs.
LF328119 - JP 2014500723-A/135622: Polycomb-Associated Non-Coding RNAs.
LF328120 - JP 2014500723-A/135623: Polycomb-Associated Non-Coding RNAs.
JD027094 - Sequence 8118 from Patent EP1572962.
JD034082 - Sequence 15106 from Patent EP1572962.
LF328121 - JP 2014500723-A/135624: Polycomb-Associated Non-Coding RNAs.
JD028311 - Sequence 9335 from Patent EP1572962.
JD024669 - Sequence 5693 from Patent EP1572962.
LF328122 - JP 2014500723-A/135625: Polycomb-Associated Non-Coding RNAs.
LF328123 - JP 2014500723-A/135626: Polycomb-Associated Non-Coding RNAs.
JD095986 - Sequence 77010 from Patent EP1572962.
JD509147 - Sequence 490171 from Patent EP1572962.
LF328124 - JP 2014500723-A/135627: Polycomb-Associated Non-Coding RNAs.
JD264856 - Sequence 245880 from Patent EP1572962.
JD489697 - Sequence 470721 from Patent EP1572962.
JD507703 - Sequence 488727 from Patent EP1572962.
JD553063 - Sequence 534087 from Patent EP1572962.
JD296397 - Sequence 277421 from Patent EP1572962.
LF328125 - JP 2014500723-A/135628: Polycomb-Associated Non-Coding RNAs.
JD475407 - Sequence 456431 from Patent EP1572962.
JD320349 - Sequence 301373 from Patent EP1572962.
LF328126 - JP 2014500723-A/135629: Polycomb-Associated Non-Coding RNAs.
JD023831 - Sequence 4855 from Patent EP1572962.
JD021042 - Sequence 2066 from Patent EP1572962.
MA563696 - JP 2018138019-A/135622: Polycomb-Associated Non-Coding RNAs.
MA563697 - JP 2018138019-A/135623: Polycomb-Associated Non-Coding RNAs.
MA563698 - JP 2018138019-A/135624: Polycomb-Associated Non-Coding RNAs.
MA563699 - JP 2018138019-A/135625: Polycomb-Associated Non-Coding RNAs.
MA563700 - JP 2018138019-A/135626: Polycomb-Associated Non-Coding RNAs.
MA563701 - JP 2018138019-A/135627: Polycomb-Associated Non-Coding RNAs.
MA563702 - JP 2018138019-A/135628: Polycomb-Associated Non-Coding RNAs.
MA563703 - JP 2018138019-A/135629: Polycomb-Associated Non-Coding RNAs.
LF328127 - JP 2014500723-A/135630: Polycomb-Associated Non-Coding RNAs.
JD446204 - Sequence 427228 from Patent EP1572962.
LF328129 - JP 2014500723-A/135632: Polycomb-Associated Non-Coding RNAs.
LF328130 - JP 2014500723-A/135633: Polycomb-Associated Non-Coding RNAs.
CU679998 - Synthetic construct Homo sapiens gateway clone IMAGE:100020474 5' read CDC27 mRNA.
LF328131 - JP 2014500723-A/135634: Polycomb-Associated Non-Coding RNAs.
LF328132 - JP 2014500723-A/135635: Polycomb-Associated Non-Coding RNAs.
DQ786193 - Homo sapiens clone HLS_IMAGE_109708 mRNA sequence.
JD078863 - Sequence 59887 from Patent EP1572962.
JD250379 - Sequence 231403 from Patent EP1572962.
JD059773 - Sequence 40797 from Patent EP1572962.
JD219196 - Sequence 200220 from Patent EP1572962.
MA563704 - JP 2018138019-A/135630: Polycomb-Associated Non-Coding RNAs.
MA563706 - JP 2018138019-A/135632: Polycomb-Associated Non-Coding RNAs.
MA563707 - JP 2018138019-A/135633: Polycomb-Associated Non-Coding RNAs.
MA563708 - JP 2018138019-A/135634: Polycomb-Associated Non-Coding RNAs.
MA563709 - JP 2018138019-A/135635: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04114 - Oocyte meiosis
hsa04120 - Ubiquitin mediated proteolysis
hsa04914 - Progesterone-mediated oocyte maturation

-  Other Names for This Gene
  Alternate Gene Symbols: G3V1C4, G3V1C4_HUMAN, hCG_1993274, NM_001114091, NP_001107563
UCSC ID: uc002ile.4
RefSeq Accession: NM_001114091
Protein: G3V1C4 CCDS: CCDS11509.1, CCDS45720.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001114091.1
exon count: 19CDS single in 3' UTR: no RNA size: 5611
ORF size: 2493CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5020.50frame shift in genome: no % Coverage: 99.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.