Human Gene CEP85L (uc003pxz.2) Description and Page Index
Description: Homo sapiens centrosomal protein 85kDa-like (CEP85L), transcript variant 1, mRNA. RefSeq Summary (NM_001042475): The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr6:118,781,935-118,973,020 Size: 191,086 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chr6:118,786,568-118,972,432 Size: 185,865 Coding Exon Count: 13
ID:CE85L_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 85 kDa-like; AltName: Full=Serologically defined breast cancer antigen NY-BR-15; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (Probable). Note=Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association. TISSUE SPECIFICITY: Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL) patients. DISEASE: Note=A chromosomal aberration involving CEP85L is found in a patient with T-lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with PDGFRB. The translocation fuses the 5'-end of CEP85L (isoform 4) to the 3'-end of PDGFRB. SIMILARITY: Belongs to the CEP85 family. SEQUENCE CAUTION: Sequence=AAI10836.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAM19611.1; Type=Erroneous gene model prediction; Sequence=CAM28257.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q5SZL2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.