Description: Homo sapiens creatine kinase, muscle (CKM), mRNA. RefSeq Summary (NM_001824): The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:45,809,671-45,826,235 Size: 16,565 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr19:45,810,008-45,822,971 Size: 12,964 Coding Exon Count: 7
ID:KCRM_HUMAN DESCRIPTION: RecName: Full=Creatine kinase M-type; EC=2.7.3.2; AltName: Full=Creatine kinase M chain; AltName: Full=M-CK; FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine. SUBUNIT: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the ATP:guanido phosphotransferase family. SIMILARITY: Contains 1 phosphagen kinase C-terminal domain. SIMILARITY: Contains 1 phosphagen kinase N-terminal domain. WEB RESOURCE: Name=Wikipedia; Note=Creatine kinase entry; URL="http://en.wikipedia.org/wiki/Creatine_kinase"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ckm/"; WEB RESOURCE: Name=Wikipedia; Note=CKM entry; URL="http://en.wikipedia.org/wiki/CKM_(gene)";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CKM CDC HuGE Published Literature: CKM Positive Disease Associations: endurance performance Related Studies:
endurance performance Duoqi, Z. et al. 2006, CKMM Gene Polymorphism and Running Economy responses to a 18-week 5000 m training program, Br J Sports Med 2006.
[PubMed 17000714]
The findings indicate that the CKMM gene polymorphism may contribute to individual running economy responses to endurance training.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P06732
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
