Description: Homo sapiens cut-like homeobox 1 (CUX1), transcript variant 1, mRNA. RefSeq Summary (NM_181552): The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]. Transcript (Including UTRs) Position: hg19 chr7:101,460,882-101,901,513 Size: 440,632 Total Exon Count: 24 Strand: + Coding Region Position: hg19 chr7:101,460,920-101,892,322 Size: 431,403 Coding Exon Count: 24
ID:CUX1_HUMAN DESCRIPTION: RecName: Full=Homeobox protein cut-like 1; AltName: Full=CCAAT displacement protein; Short=CDP; AltName: Full=Homeobox protein cux-1; FUNCTION: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). SUBUNIT: Interacts with BANP (By similarity). SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization. SIMILARITY: Belongs to the CUT homeobox family. SIMILARITY: Contains 3 CUT DNA-binding domains. SIMILARITY: Contains 1 homeobox DNA-binding domain.
Genetic Association Studies of Complex Diseases and Disorders
Inflammatory Bowel Diseases Richard H Duerr et al. Science (New York, N.Y.) 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene., Science (New York, N.Y.).
[PubMed 17068223]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P39880
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0003677 DNA binding GO:0004713 protein tyrosine kinase activity GO:0030674 protein binding, bridging GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000301 retrograde transport, vesicle recycling within Golgi GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0018108 peptidyl-tyrosine phosphorylation GO:0048193 Golgi vesicle transport GO:0050775 positive regulation of dendrite morphogenesis
US Server
