Description: Homo sapiens cytochrome P450, family 2, subfamily S, polypeptide 1 (CYP2S1), mRNA. RefSeq Summary (NM_030622): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:41,699,115-41,713,444 Size: 14,330 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr19:41,699,170-41,712,393 Size: 13,224 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96SQ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0005515 protein binding GO:0008392 arachidonic acid epoxygenase activity GO:0008395 steroid hydroxylase activity GO:0008401 retinoic acid 4-hydroxylase activity GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0020037 heme binding GO:0046872 metal ion binding GO:0070330 aromatase activity
Biological Process: GO:0019373 epoxygenase P450 pathway GO:0055114 oxidation-reduction process
AK027605 - Homo sapiens cDNA FLJ14699 fis, clone NT2RP2006571, moderately similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). AY358603 - Homo sapiens clone DNA76395 Cytochrome p450 (UNQ891) mRNA, complete cds. AK296087 - Homo sapiens cDNA FLJ52866 complete cds, highly similar to Cytochrome P450 2S1 (EC 1.14.14.1). BC033691 - Homo sapiens cytochrome P450, family 2, subfamily S, polypeptide 1, mRNA (cDNA clone MGC:44853 IMAGE:5212609), complete cds. CU689700 - Synthetic construct Homo sapiens gateway clone IMAGE:100019707 5' read CYP2S1 mRNA. DQ893363 - Synthetic construct clone IMAGE:100005993; FLH196613.01X; RZPDo839F10156D cytochrome P450, family 2, subfamily S, polypeptide 1 (CYP2S1) gene, encodes complete protein. DQ896681 - Synthetic construct Homo sapiens clone IMAGE:100011141; FLH196609.01L; RZPDo839F10155D cytochrome P450, family 2, subfamily S, polypeptide 1 (CYP2S1) gene, encodes complete protein. KJ898726 - Synthetic construct Homo sapiens clone ccsbBroadEn_08120 CYP2S1 gene, encodes complete protein. AF335278 - Homo sapiens cytochrome P450 2S1 (CYP2S1) mRNA, complete cds. JD222110 - Sequence 203134 from Patent EP1572962. JD386503 - Sequence 367527 from Patent EP1572962. JD096852 - Sequence 77876 from Patent EP1572962. JD095714 - Sequence 76738 from Patent EP1572962. JD424230 - Sequence 405254 from Patent EP1572962. JD494067 - Sequence 475091 from Patent EP1572962. JD049622 - Sequence 30646 from Patent EP1572962. JD050715 - Sequence 31739 from Patent EP1572962. JD537130 - Sequence 518154 from Patent EP1572962. JD154170 - Sequence 135194 from Patent EP1572962. JD432387 - Sequence 413411 from Patent EP1572962. JD542427 - Sequence 523451 from Patent EP1572962. JD211961 - Sequence 192985 from Patent EP1572962. JD120712 - Sequence 101736 from Patent EP1572962. JD351983 - Sequence 333007 from Patent EP1572962. JD190893 - Sequence 171917 from Patent EP1572962. JD334434 - Sequence 315458 from Patent EP1572962. JD189534 - Sequence 170558 from Patent EP1572962. JD392586 - Sequence 373610 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00980 - Metabolism of xenobiotics by cytochrome P450
BioCyc Knowledge Library PWY66-201 - nicotine degradation II PWY66-221 - nicotine degradation III PWY66-241 - bupropion degradation
Reactome (by CSHL, EBI, and GO)
Protein Q96SQ9 (Reactome details) participates in the following event(s):
R-HSA-211874 CYP2S1 4-hydroxylates atRA R-HSA-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide R-HSA-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) R-HSA-76416 Benzene is hydroxylated to phenol R-HSA-76434 Dehalogenation of carbon tetrachloride to form a free radical R-HSA-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide R-HSA-143468 MEOS oxidizes ethanol to acetaldehyde R-HSA-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation R-HSA-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation R-HSA-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 R-HSA-212005 CYP2F1 dehydrogenates 3-methylindole R-HSA-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation R-HSA-211929 CYP2C19 5-hydroxylates omeprazole R-HSA-211958 Miscellaneous substrates R-HSA-211999 CYP2E1 reactions R-HSA-211981 Xenobiotics R-HSA-211897 Cytochrome P450 - arranged by substrate type R-HSA-211945 Phase I - Functionalization of compounds R-HSA-211859 Biological oxidations R-HSA-1430728 Metabolism