Description: Homo sapiens dynein, cytoplasmic 1, intermediate chain 2 (DYNC1I2), transcript variant 1, mRNA. RefSeq Summary (NM_001378): This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr2:172,543,919-172,606,668 Size: 62,750 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr2:172,546,666-172,604,399 Size: 57,734 Coding Exon Count: 17
ID:DC1I2_HUMAN DESCRIPTION: RecName: Full=Cytoplasmic dynein 1 intermediate chain 2; AltName: Full=Cytoplasmic dynein intermediate chain 2; AltName: Full=Dynein intermediate chain 2, cytosolic; Short=DH IC-2; FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. SUBUNIT: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding (By similarity). SIMILARITY: Belongs to the dynein intermediate chain family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=AAA89166.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DYNC1I2 CDC HuGE Published Literature: DYNC1I2 Positive Disease Associations: Body Height Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13409
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0006888 ER to Golgi vesicle-mediated transport GO:0007018 microtubule-based movement GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010970 transport along microtubule GO:0016032 viral process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0097711 ciliary basal body docking GO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed