Human Gene FAM114A2 (uc003lvb.3)
  Description: Homo sapiens family with sequence similarity 114, member A2 (FAM114A2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:153,371,269-153,418,426 Size: 47,158 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr5:153,372,536-153,414,513 Size: 41,978 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:153,371,269-153,418,426)mRNA (may differ from genome)Protein (505 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  Comments and Description Text from UniProtKB
  ID: F1142_HUMAN
DESCRIPTION: RecName: Full=Protein FAM114A2;
SIMILARITY: Belongs to the FAM114 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.53 RPKM in Testis
Total median expression: 172.86 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -203.40588-0.346 Picture PostScript Text
3' UTR -309.721267-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007998 - DUF719

Pfam Domains:
PF05334 - Protein of unknown function (DUF719)

ModBase Predicted Comparative 3D Structure on Q9NRY5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017076 purine nucleotide binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component

-  Descriptions from all associated GenBank mRNAs
  AF159700 - Homo sapiens clone 133K02 unknown mRNA.
HM005704 - Homo sapiens clone HTL-T-81P testis tissue sperm-binding protein Li 81P mRNA, complete cds.
AK024664 - Homo sapiens cDNA: FLJ21011 fis, clone CAE04289.
AK095446 - Homo sapiens cDNA FLJ38127 fis, clone D6OST2000245.
JD086762 - Sequence 67786 from Patent EP1572962.
JD300087 - Sequence 281111 from Patent EP1572962.
JD126431 - Sequence 107455 from Patent EP1572962.
JD055408 - Sequence 36432 from Patent EP1572962.
JD341246 - Sequence 322270 from Patent EP1572962.
JD246059 - Sequence 227083 from Patent EP1572962.
JD404261 - Sequence 385285 from Patent EP1572962.
JD085267 - Sequence 66291 from Patent EP1572962.
AK225821 - Homo sapiens mRNA for hypothetical protein LOC10827 variant, clone: FCC128G05.
BC011414 - Homo sapiens family with sequence similarity 114, member A2, mRNA (cDNA clone MGC:16827 IMAGE:3855873), complete cds.
BC050701 - Homo sapiens family with sequence similarity 114, member A2, mRNA (cDNA clone IMAGE:3915060), complete cds.
AK303865 - Homo sapiens cDNA FLJ54229 complete cds.
JD515075 - Sequence 496099 from Patent EP1572962.
JD345933 - Sequence 326957 from Patent EP1572962.
DQ591418 - Homo sapiens piRNA piR-58530, complete sequence.
AK298943 - Homo sapiens cDNA FLJ56229 complete cds.
AK313331 - Homo sapiens cDNA, FLJ93853.
JF432278 - Synthetic construct Homo sapiens clone IMAGE:100073450 family with sequence similarity 114, member A2 (C5orf3) gene, encodes complete protein.
KJ898294 - Synthetic construct Homo sapiens clone ccsbBroadEn_07688 FAM114A2 gene, encodes complete protein.
CU679932 - Synthetic construct Homo sapiens gateway clone IMAGE:100020302 5' read C5orf3 mRNA.
JD097008 - Sequence 78032 from Patent EP1572962.
JD263850 - Sequence 244874 from Patent EP1572962.
JD061991 - Sequence 43015 from Patent EP1572962.
JD349977 - Sequence 331001 from Patent EP1572962.
JD139036 - Sequence 120060 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NRY5 (Reactome details) participates in the following event(s):

R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: AF159700, B2R8D8, C5orf3, F1142_HUMAN, NM_018691, NP_061161, Q9H7E0, Q9NRY5
UCSC ID: uc003lvb.3
RefSeq Accession: NM_018691
Protein: Q9NRY5 (aka F1142_HUMAN)
CCDS: CCDS4323.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AF159700.1
exon count: 14CDS single in 3' UTR: no RNA size: 3379
ORF size: 1518CDS single in intron: no Alignment % ID: 99.67
txCdsPredict score: 2637.00frame shift in genome: no % Coverage: 99.79
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 432# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.