Human Gene FCHSD1 (uc003llk.3)
  Description: Homo sapiens FCH and double SH3 domains 1 (FCHSD1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:141,018,869-141,030,986 Size: 12,118 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr5:141,021,065-141,030,935 Size: 9,871 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:141,018,869-141,030,986)mRNA (may differ from genome)Protein (690 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer
GeneCardsGeneNetworkH-INVHGNCHPRDLynx
MGIneXtProtOMIMPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: FCSD1_HUMAN
DESCRIPTION: RecName: Full=FCH and double SH3 domains protein 1;
SIMILARITY: Contains 1 FCH domain.
SIMILARITY: Contains 2 SH3 domains.
SEQUENCE CAUTION: Sequence=BAA92232.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FCHSD1
CDC HuGE Published Literature: FCHSD1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.31 RPKM in Spleen
Total median expression: 319.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.8051-0.388 Picture PostScript Text
3' UTR -980.742196-0.447 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001060 - FCH
IPR011511 - SH3_2
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain
PF00611 - Fes/CIP4, and EFC/F-BAR homology domain
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on Q86WN1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007274 neuromuscular synaptic transmission
GO:0030833 regulation of actin filament polymerization

Cellular Component:
GO:0031594 neuromuscular junction
GO:0055037 recycling endosome


-  Descriptions from all associated GenBank mRNAs
  AY217346 - Homo sapiens FLJ00007-like protein mRNA, complete cds.
AK126203 - Homo sapiens cDNA FLJ44215 fis, clone THYMU3003565.
AK000007 - Homo sapiens FLJ00007 mRNA for FLJ00007 protein.
AK027281 - Homo sapiens cDNA FLJ14375 fis, clone HEMBA1001655.
AY358478 - Homo sapiens clone DNA73401 QLAK737 (UNQ737) mRNA, complete cds.
JD054364 - Sequence 35388 from Patent EP1572962.
JD429260 - Sequence 410284 from Patent EP1572962.
JD528385 - Sequence 509409 from Patent EP1572962.
JD045985 - Sequence 27009 from Patent EP1572962.
JD538173 - Sequence 519197 from Patent EP1572962.
JD300129 - Sequence 281153 from Patent EP1572962.
JD067753 - Sequence 48777 from Patent EP1572962.
JD389267 - Sequence 370291 from Patent EP1572962.
JD230650 - Sequence 211674 from Patent EP1572962.
JD384987 - Sequence 366011 from Patent EP1572962.
JD369720 - Sequence 350744 from Patent EP1572962.
JD319941 - Sequence 300965 from Patent EP1572962.
JD132941 - Sequence 113965 from Patent EP1572962.
JD481653 - Sequence 462677 from Patent EP1572962.
JD394555 - Sequence 375579 from Patent EP1572962.
JD492123 - Sequence 473147 from Patent EP1572962.
JD525263 - Sequence 506287 from Patent EP1572962.
JD544214 - Sequence 525238 from Patent EP1572962.
JD120274 - Sequence 101298 from Patent EP1572962.
JD273699 - Sequence 254723 from Patent EP1572962.
JD233844 - Sequence 214868 from Patent EP1572962.
JD083948 - Sequence 64972 from Patent EP1572962.
JD213523 - Sequence 194547 from Patent EP1572962.
JD544157 - Sequence 525181 from Patent EP1572962.
JD518357 - Sequence 499381 from Patent EP1572962.
JD365357 - Sequence 346381 from Patent EP1572962.
JD445874 - Sequence 426898 from Patent EP1572962.
JD383850 - Sequence 364874 from Patent EP1572962.
JD172961 - Sequence 153985 from Patent EP1572962.
JD452978 - Sequence 434002 from Patent EP1572962.
JD483673 - Sequence 464697 from Patent EP1572962.
JD248900 - Sequence 229924 from Patent EP1572962.
JD077329 - Sequence 58353 from Patent EP1572962.
JD415576 - Sequence 396600 from Patent EP1572962.
BC047016 - Homo sapiens FCH and double SH3 domains 1, mRNA (cDNA clone MGC:54314 IMAGE:5215830), complete cds.
AF086518 - Homo sapiens full length insert cDNA clone ZE04A10.
JD473894 - Sequence 454918 from Patent EP1572962.
JD048492 - Sequence 29516 from Patent EP1572962.
JD071739 - Sequence 52763 from Patent EP1572962.
JD195561 - Sequence 176585 from Patent EP1572962.
JD543440 - Sequence 524464 from Patent EP1572962.
JD488213 - Sequence 469237 from Patent EP1572962.
JD426278 - Sequence 407302 from Patent EP1572962.
JD435238 - Sequence 416262 from Patent EP1572962.
JD376846 - Sequence 357870 from Patent EP1572962.
JD434619 - Sequence 415643 from Patent EP1572962.
JD248099 - Sequence 229123 from Patent EP1572962.
JD086020 - Sequence 67044 from Patent EP1572962.
AB527141 - Synthetic construct DNA, clone: pF1KF0007, Homo sapiens FCHSD1 gene for FCH and double SH3 domains 1, without stop codon, in Flexi system.
CU692352 - Synthetic construct Homo sapiens gateway clone IMAGE:100021351 5' read FCHSD1 mRNA.
JD309631 - Sequence 290655 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: FCSD1_HUMAN, NM_033449, NP_258260, Q6UX75, Q86WN1, Q86Y77, Q9NXX8, UNQ737/PRO1431
UCSC ID: uc003llk.3
RefSeq Accession: NM_033449
Protein: Q86WN1 (aka FCSD1_HUMAN)
CCDS: CCDS47295.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033449.2
exon count: 20CDS single in 3' UTR: no RNA size: 4333
ORF size: 2073CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4164.00frame shift in genome: no % Coverage: 99.70
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.