Description: Homo sapiens forkhead box K2 (FOXK2), mRNA. RefSeq Summary (NM_004514): The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:80,477,594-80,562,483 Size: 84,890 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr17:80,477,765-80,559,375 Size: 81,611 Coding Exon Count: 9
ID:FOXK2_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein K2; AltName: Full=Cellular transcription factor ILF-1; AltName: Full=FOXK1; AltName: Full=Interleukin enhancer-binding factor 1; FUNCTION: Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. COFACTOR: Binds 1 magnesium ion per subunit. INTERACTION: P14316:IRF2; NbExp=2; IntAct=EBI-2509991, EBI-2866589; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in both lymphoid and non-lymphoid cells. DOMAIN: The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 fork-head DNA-binding domain. SEQUENCE CAUTION: Sequence=AAB02820.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors; Sequence=AAB02821.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors; Sequence=AAB02822.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01167
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000287 magnesium ion binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0009653 anatomical structure morphogenesis GO:0016579 protein deubiquitination GO:0030154 cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
