Description: Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (GNAI1), transcript variant 1, mRNA. RefSeq Summary (NM_002069): Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. Transcript (Including UTRs) Position: hg19 chr7:79,764,140-79,848,725 Size: 84,586 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr7:79,764,477-79,846,809 Size: 82,333 Coding Exon Count: 8
ID:GNAI1_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-1; AltName: Full=Adenylate cyclase-inhibiting G alpha protein; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. SUBUNIT: Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. INTERACTION: P81274:GPSM2; NbExp=3; IntAct=EBI-618639, EBI-618655; Q14980:NUMA1; NbExp=4; IntAct=EBI-618639, EBI-521611; SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GNAI1 CDC HuGE Published Literature: GNAI1 Positive Disease Associations: Body Mass Index
, Heart Failure Related Studies:
Body Mass Index Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P63096
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P63096 (Reactome details) participates in the following event(s):
R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-392212 G alpha (i) auto-inactivates by hydrolysing GTP to GDP R-HSA-392202 Dissociation of the P2Y purinoceptor 12:Gi complex R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-751001 Inactive G alpha (i) reassociates with G beta:gamma R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit R-HSA-112037 Inactivation of PLC beta R-HSA-167415 G-protein alpha subunit is inactivated R-HSA-111870 Activation of PLC beta-1/4 R-HSA-112271 The receptor:G-protein complex dissociates R-HSA-167429 The receptor:G-protein complex binds GTP R-HSA-400037 Gi,Go Heterotrimeric G-protein complex dissociates R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-392187 Activated P2Y purinoceptor 12 binds G-protein Gi R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-167408 The high affinity receptor complex binds to G-protein R-HSA-167419 The receptor:G-protein complex releases GDP R-HSA-400092 Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins R-HSA-392195 Gi activation by P2Y purinoceptor 12 R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-111879 PIP2 hydrolysis R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-392170 ADP signalling through P2Y purinoceptor 12 R-HSA-202040 G-protein activation R-HSA-112043 PLC beta mediated events R-HSA-390466 Chaperonin-mediated protein folding R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-388396 GPCR downstream signalling R-HSA-392518 Signal amplification R-HSA-111885 Opioid Signalling R-HSA-391251 Protein folding R-HSA-422356 Regulation of insulin secretion R-HSA-991365 Activation of GABAB receptors R-HSA-372790 Signaling by GPCR R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-392499 Metabolism of proteins R-HSA-163685 Energy Metabolism R-HSA-977444 GABA B receptor activation R-HSA-162582 Signal Transduction R-HSA-109582 Hemostasis R-HSA-1430728 Metabolism R-HSA-977443 GABA receptor activation R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
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