ID:HID1_HUMAN DESCRIPTION: RecName: Full=Protein HID1; AltName: Full=Down-regulated in multiple cancers 1; AltName: Full=HID1 domain-containing protein; AltName: Full=Protein hid-1 homolog; FUNCTION: May play an important role in the development of cancers in a broad range of tissues. INTERACTION: O15357:INPPL1; NbExp=2; IntAct=EBI-743438, EBI-1384248; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Lipid- anchor. Note=Shuttles between the cytosol and the Golgi apparatus. TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines. SIMILARITY: Belongs to the hid-1 family. SEQUENCE CAUTION: Sequence=BAB85070.1; Type=Frameshift; Positions=594;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09742 - Dyggve-Melchior-Clausen syndrome protein PF12722 - High-temperature-induced dauer-formation protein
ModBase Predicted Comparative 3D Structure on Q8IV36
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.