Human Gene HID1 (uc002jmj.4)
  Description: Homo sapiens HID1 domain containing (HID1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:72,946,839-72,968,900 Size: 22,062 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr17:72,947,665-72,968,751 Size: 21,087 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:72,946,839-72,968,900)mRNA (may differ from genome)Protein (788 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HID1_HUMAN
DESCRIPTION: RecName: Full=Protein HID1; AltName: Full=Down-regulated in multiple cancers 1; AltName: Full=HID1 domain-containing protein; AltName: Full=Protein hid-1 homolog;
FUNCTION: May play an important role in the development of cancers in a broad range of tissues.
INTERACTION: O15357:INPPL1; NbExp=2; IntAct=EBI-743438, EBI-1384248;
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Lipid- anchor. Note=Shuttles between the cytosol and the Golgi apparatus.
TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.
SIMILARITY: Belongs to the hid-1 family.
SEQUENCE CAUTION: Sequence=BAB85070.1; Type=Frameshift; Positions=594;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HID1
Diseases sorted by gene-association score: palmoplantar keratoderma, nonepidermolytic (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 122.35 RPKM in Brain - Cerebellum
Total median expression: 917.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.20149-0.491 Picture PostScript Text
3' UTR -358.26826-0.434 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026705 - Hid-1
IPR026972 - Hid-1_metazoal

Pfam Domains:
PF09742 - Dyggve-Melchior-Clausen syndrome protein
PF12722 - High-temperature-induced dauer-formation protein

ModBase Predicted Comparative 3D Structure on Q8IV36
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
   FlyBaseWormBase 
   Protein SequenceProtein Sequence 
   AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0031001 response to brefeldin A

Cellular Component:
GO:0000138 Golgi trans cisterna
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0090498 extrinsic component of Golgi membrane


-  Descriptions from all associated GenBank mRNAs
  BC032219 - Homo sapiens chromosome 17 open reading frame 28, mRNA (cDNA clone MGC:35542 IMAGE:5200267), complete cds.
AK125514 - Homo sapiens cDNA FLJ43526 fis, clone PLACE6001185.
AK075111 - Homo sapiens cDNA FLJ90630 fis, clone PLACE1003438.
BC035372 - Homo sapiens chromosome 17 open reading frame 28, mRNA (cDNA clone MGC:35266 IMAGE:5174235), complete cds.
AK074401 - Homo sapiens cDNA FLJ23821 fis, clone HUV00353.
JC548156 - Sequence 8569 from Patent EP2699673.
JC550407 - Sequence 10820 from Patent EP2699673.
JD484865 - Sequence 465889 from Patent EP1572962.
JD563629 - Sequence 544653 from Patent EP1572962.
JD054118 - Sequence 35142 from Patent EP1572962.
JD467528 - Sequence 448552 from Patent EP1572962.
JD041113 - Sequence 22137 from Patent EP1572962.
JD398331 - Sequence 379355 from Patent EP1572962.
JD515370 - Sequence 496394 from Patent EP1572962.
AK304081 - Homo sapiens cDNA FLJ57287 complete cds.
JD044777 - Sequence 25801 from Patent EP1572962.
JD463619 - Sequence 444643 from Patent EP1572962.
JD087616 - Sequence 68640 from Patent EP1572962.
JD223756 - Sequence 204780 from Patent EP1572962.
JF432821 - Synthetic construct Homo sapiens clone IMAGE:100074139 chromosome 17 open reading frame 28 (C17orf28) gene, encodes complete protein.
KJ900555 - Synthetic construct Homo sapiens clone ccsbBroadEn_09949 C17orf28 gene, encodes complete protein.
AB527292 - Synthetic construct DNA, clone: pF1KB9562, Homo sapiens DMC1 gene for DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination, without stop codon, in Flexi system.
AL137556 - Homo sapiens mRNA; cDNA DKFZp434I1120 (from clone DKFZp434I1120).
CU690082 - Synthetic construct Homo sapiens gateway clone IMAGE:100020087 5' read C17orf28 mRNA.
AK095565 - Homo sapiens cDNA FLJ38246 fis, clone FCBBF2007265.
JD408450 - Sequence 389474 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C17orf28, DMC1, HID1_HUMAN, NM_030630, NP_085133, Q8IV36, Q8N5L6, Q8TE83, Q9NT34
UCSC ID: uc002jmj.4
RefSeq Accession: NM_030630
Protein: Q8IV36 (aka HID1_HUMAN)
CCDS: CCDS32726.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_030630.2
exon count: 19CDS single in 3' UTR: no RNA size: 3369
ORF size: 2367CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4702.00frame shift in genome: no % Coverage: 99.20
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.