ID:KDM7_HUMAN DESCRIPTION: RecName: Full=Lysine-specific demethylase 7; EC=1.14.11.-; AltName: Full=JmjC domain-containing histone demethylation protein 1D; FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. COFACTOR: Binds 1 Fe(2+) ion per subunit. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.2 uM for histone H3 H3K9Me2; SUBCELLULAR LOCATION: Nucleus. DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2. DOMAIN: The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2. SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. SIMILARITY: Contains 1 JmjC domain. SIMILARITY: Contains 1 PHD-type zinc finger. SEQUENCE CAUTION: Sequence=BAD18641.1; Type=Frameshift; Positions=902; Sequence=EAL24032.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZMT4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005506 iron ion binding GO:0008270 zinc ion binding GO:0016491 oxidoreductase activity GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0032452 histone demethylase activity GO:0032454 histone demethylase activity (H3-K9 specific) GO:0035064 methylated histone binding GO:0035575 histone demethylase activity (H4-K20 specific) GO:0046872 metal ion binding GO:0051213 dioxygenase activity GO:0051864 histone demethylase activity (H3-K36 specific) GO:0071558 histone demethylase activity (H3-K27 specific)