Description: Homo sapiens kinesin-associated protein 3 (KIFAP3), transcript variant 1, mRNA. RefSeq Summary (NM_014970): The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. Transcript (Including UTRs) Position: hg19 chr1:169,890,470-170,043,879 Size: 153,410 Total Exon Count: 20 Strand: - Coding Region Position: hg19 chr1:169,890,817-170,043,608 Size: 152,792 Coding Exon Count: 20
ID:KIFA3_HUMAN DESCRIPTION: RecName: Full=Kinesin-associated protein 3; Short=KAP-3; Short=KAP3; AltName: Full=Smg GDS-associated protein; FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). SUBUNIT: Heterotrimer of KIFAP3, KIF3A and KIF3B. Interacts with RAP1GDS1/SMG GDS. Interacts with SMC3 subunit of the cohesin complex. PTM: Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1. SIMILARITY: Contains 5 ARM repeats.
Amyotrophic lateral sclerosis Landers ,et al. 2009, Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences of the United States of America 2009 106- 22 : 9004-9.
[PubMed 19451621]
Amyotrophic Lateral Sclerosis John E Landers et al. Proceedings of the National Academy of Sciences of the United States of America 2009, Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis., Proceedings of the National Academy of Sciences of the United States of America.
[PubMed 19451621]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92845
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007017 microtubule-based process GO:0007018 microtubule-based movement GO:0007165 signal transduction GO:0008104 protein localization GO:0008285 negative regulation of cell proliferation GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0035735 intraciliary transport involved in cilium assembly GO:0043066 negative regulation of apoptotic process GO:0046587 positive regulation of calcium-dependent cell-cell adhesion GO:0065003 macromolecular complex assembly GO:0072383 plus-end-directed vesicle transport along microtubule
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
