Human Gene LSM14A (uc002nva.4)
  Description: Homo sapiens LSM14A, SCD6 homolog A (S. cerevisiae) (LSM14A), transcript variant 2, mRNA.
RefSeq Summary (NM_015578): Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr19:34,663,352-34,720,420 Size: 57,069 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr19:34,663,548-34,718,293 Size: 54,746 Coding Exon Count: 10 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:34,663,352-34,720,420)mRNA (may differ from genome)Protein (463 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  MalaCards Disease Associations
  MalaCards Gene Search: LSM14A
Diseases sorted by gene-association score: autoimmune disease of urogenital tract (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.95 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1393.74 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -119.70196-0.611 Picture PostScript Text
3' UTR -518.692127-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF09532 - FDF domain
PF12701 - Scd6-like Sm domain
PF14438 - Ataxin 2 SM domain

ModBase Predicted Comparative 3D Structure on Q8ND56-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Descriptions from all associated GenBank mRNAs
  BC016842 - Homo sapiens LSM14A, SCD6 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:10135 IMAGE:3902704), complete cds.
LF384249 - JP 2014500723-A/191752: Polycomb-Associated Non-Coding RNAs.
AK300208 - Homo sapiens cDNA FLJ54754 complete cds, highly similar to Protein FAM61A.
AL834398 - Homo sapiens mRNA; cDNA DKFZp547L1110 (from clone DKFZp547L1110).
LF367520 - JP 2014500723-A/175023: Polycomb-Associated Non-Coding RNAs.
AK027643 - Homo sapiens cDNA FLJ14737 fis, clone NT2RP3002273, weakly similar to SCD6 PROTEIN.
AB069974 - Homo sapiens mRNA for alphaSNBP(A), complete cds.
AB069975 - Homo sapiens mRNA for alphaSNBP(B), complete cds.
JD419550 - Sequence 400574 from Patent EP1572962.
LF367518 - JP 2014500723-A/175021: Polycomb-Associated Non-Coding RNAs.
KJ898590 - Synthetic construct Homo sapiens clone ccsbBroadEn_07984 LSM14A gene, encodes complete protein.
AB384376 - Synthetic construct DNA, clone: pF1KSDB0041, Homo sapiens LSM14A gene for LSM14 protein homolog A, complete cds, without stop codon, in Flexi system.
AK027369 - Homo sapiens cDNA FLJ14463 fis, clone MAMMA1000284, moderately similar to P.walti mRNA for rnp associated protein 55.
AL833221 - Homo sapiens mRNA; cDNA DKFZp667H157 (from clone DKFZp667H157).
AK127401 - Homo sapiens cDNA FLJ45492 fis, clone BRTHA2008502.
AL117499 - Homo sapiens mRNA; cDNA DKFZp434D1335 (from clone DKFZp434D1335).
JD019898 - Sequence 922 from Patent EP1572962.
JD145986 - Sequence 127010 from Patent EP1572962.
JD028673 - Sequence 9697 from Patent EP1572962.
JD520490 - Sequence 501514 from Patent EP1572962.
JD088178 - Sequence 69202 from Patent EP1572962.
JD281214 - Sequence 262238 from Patent EP1572962.
JD427926 - Sequence 408950 from Patent EP1572962.
JD220372 - Sequence 201396 from Patent EP1572962.
JD186055 - Sequence 167079 from Patent EP1572962.
JD245477 - Sequence 226501 from Patent EP1572962.
JD278145 - Sequence 259169 from Patent EP1572962.
JD299640 - Sequence 280664 from Patent EP1572962.
JD515895 - Sequence 496919 from Patent EP1572962.
JD507490 - Sequence 488514 from Patent EP1572962.
JD500338 - Sequence 481362 from Patent EP1572962.
JD188235 - Sequence 169259 from Patent EP1572962.
JD428489 - Sequence 409513 from Patent EP1572962.
MA619826 - JP 2018138019-A/191752: Polycomb-Associated Non-Coding RNAs.
MA603097 - JP 2018138019-A/175023: Polycomb-Associated Non-Coding RNAs.
MA603095 - JP 2018138019-A/175021: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf13, FAM61A, NM_015578, NP_056393, Q8ND56-2, RAP55, RAP55A
UCSC ID: uc002nva.4
RefSeq Accession: NM_015578
Protein: Q8ND56-2, splice isoform of Q8ND56 CCDS: CCDS12435.1, CCDS46040.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_015578.2
exon count: 10CDS single in 3' UTR: no RNA size: 3715
ORF size: 1392CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2957.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.