Description: Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), mRNA. RefSeq Summary (NM_012090): This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq encodes the Macf1a isoform of this gene (PMID: 16076900). Transcript (Including UTRs) Position: hg19 chr1:39,549,839-39,952,810 Size: 402,972 Total Exon Count: 92 Strand: + Coding Region Position: hg19 chr1:39,549,891-39,951,466 Size: 401,576 Coding Exon Count: 92
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UPN3-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.