Description: Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), mRNA. RefSeq Summary (NM_006609): The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Transcript (Including UTRs) Position: hg19 chr2:128,056,245-128,100,805 Size: 44,561 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr2:128,065,155-128,100,705 Size: 35,551 Coding Exon Count: 16
ID:M3K2_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase 2; EC=2.7.11.25; AltName: Full=MAPK/ERK kinase kinase 2; Short=MEK kinase 2; Short=MEKK 2; FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-524 (By similarity). SUBUNIT: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. PTM: Autophosphorylated (By similarity). PTM: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAC11348.1; Type=Erroneous initiation;
Glucose James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903298]
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2U5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000186 activation of MAPKK activity GO:0000187 activation of MAPK activity GO:0006468 protein phosphorylation GO:0007257 activation of JUN kinase activity GO:0007346 regulation of mitotic cell cycle GO:0016310 phosphorylation GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0071260 cellular response to mechanical stimulus
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
