Description: Homo sapiens membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase (MARCHF10), transcript variant 1, mRNA. RefSeq Summary (NM_152598): MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]. Transcript (Including UTRs) Position: hg19 chr17:60,778,675-60,885,705 Size: 107,031 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr17:60,779,064-60,879,096 Size: 100,033 Coding Exon Count: 10
ID:MARHA_HUMAN DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase MARCH10; EC=6.3.2.-; AltName: Full=Membrane-associated RING finger protein 10; AltName: Full=Membrane-associated RING-CH protein X; Short=MARCH-X; AltName: Full=RING finger protein 190; FUNCTION: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. PATHWAY: Protein modification; protein ubiquitination. DOMAIN: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity). SIMILARITY: Contains 1 RING-CH-type zinc finger. SEQUENCE CAUTION: Sequence=AAH35021.1; Type=Erroneous termination; Positions=658; Note=Translated as Leu; Sequence=BAC05079.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NA82
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
