Human Gene MN1 (uc003adj.3) Description and Page Index
Description: Homo sapiens meningioma (disrupted in balanced translocation) 1 (MN1), mRNA. RefSeq Summary (NM_002430): Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X82209.2, SRR1660809.155500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMN03465404 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302326.5/ ENSP00000304956.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr22:28,144,265-28,197,486 Size: 53,222 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr22:28,146,903-28,196,531 Size: 49,629 Coding Exon Count: 2
ID:MN1_HUMAN DESCRIPTION: RecName: Full=Probable tumor suppressor protein MN1; FUNCTION: May play a role in tumor suppression. TISSUE SPECIFICITY: Ubiquitously expressed. Highest levels in skeletal muscle. DISEASE: Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. DISEASE: Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MN1.html";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MN1 CDC HuGE Published Literature: MN1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q10571
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.