Human Gene MZT1 (uc001viu.2)
  Description: Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:73,282,495-73,301,938 Size: 19,444 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr13:73,284,460-73,301,740 Size: 17,281 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:73,282,495-73,301,938)mRNA (may differ from genome)Protein (82 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer
GeneCardsGeneNetworkH-INVHGNCHPRDLynx
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: MZT1_HUMAN
DESCRIPTION: RecName: Full=Mitotic-spindle organizing protein 1; AltName: Full=Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1;
FUNCTION: Required for gamma-tubulin complex recruitment to the centrosome.
SUBUNIT: Part of the gamma-tubulin complex. Interacts with TUBG1.
INTERACTION: P23258:TUBG1; NbExp=2; IntAct=EBI-2637198, EBI-302589;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle.
SIMILARITY: Belongs to the MOZART1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.26 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 381.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.10198-0.435 Picture PostScript Text
3' UTR -438.511965-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022214 - DUF3743

Pfam Domains:
PF12554 - Mitotic-spindle organizing gamma-tubulin ring associated

ModBase Predicted Comparative 3D Structure on Q08AG7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding

Biological Process:
GO:0033566 gamma-tubulin complex localization
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0090307 mitotic spindle assembly
GO:0051417 microtubule nucleation by spindle pole body

Cellular Component:
GO:0000923 equatorial microtubule organizing center
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008274 gamma-tubulin ring complex
GO:0031021 interphase microtubule organizing center
GO:0061495 gamma-tubulin small complex, mitotic spindle pole body


-  Descriptions from all associated GenBank mRNAs
  BC047655 - Homo sapiens similar to RIKEN cDNA 2410129H14, mRNA (cDNA clone IMAGE:5263527).
BC062361 - Homo sapiens similar to RIKEN cDNA 2410129H14, mRNA (cDNA clone IMAGE:5474979).
AK025522 - Homo sapiens cDNA: FLJ21869 fis, clone HEP02442.
BC125183 - Homo sapiens chromosome 13 open reading frame 37, mRNA (cDNA clone MGC:150539 IMAGE:40122127), complete cds.
BC080523 - Homo sapiens similar to RIKEN cDNA 2410129H14, mRNA (cDNA clone IMAGE:4304644).
BC013405 - Homo sapiens cDNA clone IMAGE:2960331, partial cds.
KJ900768 - Synthetic construct Homo sapiens clone ccsbBroadEn_10162 MZT1 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q08AG7 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: C13orf37, MOZART1, MZT1_HUMAN, NM_001071775, NP_001065243, Q08AG7, Q5W0P5
UCSC ID: uc001viu.2
RefSeq Accession: NM_001071775
Protein: Q08AG7 (aka MZT1_HUMAN)
CCDS: CCDS31990.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001071775.2
exon count: 3CDS single in 3' UTR: no RNA size: 2412
ORF size: 249CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 479.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.