ID:OBP2B_HUMAN DESCRIPTION: RecName: Full=Odorant-binding protein 2b; AltName: Full=Odorant-binding protein IIb; Short=OBPIIb; Flags: Precursor; FUNCTION: Probably binds and transports small hydrophobic volatile molecules. SUBCELLULAR LOCATION: Secreted (Probable). TISSUE SPECIFICITY: Strongly expressed in genital sphere organs such as the prostate and mammary glands. SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): OBP2B CDC HuGE Published Literature: OBP2B Positive Disease Associations: E-Selectin Related Studies:
E-Selectin Andrew D Paterson et al. Arteriosclerosis, thrombosis, and vascular biology 2009, Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin., Arteriosclerosis, thrombosis, and vascular biology.
[PubMed 19729612]
ABO is a major locus for serum soluble E-selectin levels. We excluded population stratification, fine-mapped the association to sub-A alleles, and also document association with additional variation in the ABO region.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NPH6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005549 odorant binding GO:0036094 small molecule binding
Biological Process: GO:0007608 sensory perception of smell GO:0007635 chemosensory behavior GO:0050896 response to stimulus
Cellular Component: GO:0005575 cellular_component GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
AY358981 - Homo sapiens clone DNA65404 OBP2B (UNQ653) mRNA, complete cds. AJ251026 - Homo sapiens mRNA for putative odorant binding protein b-a (OBPIIb gene). AJ251027 - Homo sapiens mRNA for putative odorant binding protein bb (OBPIIb gene). AJ251028 - Homo sapiens mRNA for putative odorant binding protein bg (OBPIIb gene). JD402359 - Sequence 383383 from Patent EP1572962. JD464251 - Sequence 445275 from Patent EP1572962. JD394023 - Sequence 375047 from Patent EP1572962. BC096717 - Homo sapiens odorant binding protein 2B, mRNA (cDNA clone MGC:119025 IMAGE:40003080), complete cds. BC098125 - Homo sapiens odorant binding protein 2B, mRNA (cDNA clone MGC:119023 IMAGE:40003075), complete cds. BC098151 - Homo sapiens odorant binding protein 2B, mRNA (cDNA clone MGC:119024 IMAGE:40003079), complete cds. BC098340 - Homo sapiens odorant binding protein 2B, mRNA (cDNA clone MGC:119022 IMAGE:40003073), complete cds. JD121779 - Sequence 102803 from Patent EP1572962.