Description: Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), mRNA. RefSeq Summary (NM_005443): Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr4:108,534,822-108,641,419 Size: 106,598 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr4:108,535,405-108,641,335 Size: 105,931 Coding Exon Count: 12
ID:PAPS1_HUMAN DESCRIPTION: RecName: Full=Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Short=PAPS synthase 1; Short=PAPSS 1; AltName: Full=Sulfurylase kinase 1; Short=SK 1; Short=SK1; Includes: RecName: Full=Sulfate adenylyltransferase; EC=2.7.7.4; AltName: Full=ATP-sulfurylase; AltName: Full=Sulfate adenylate transferase; Short=SAT; Includes: RecName: Full=Adenylyl-sulfate kinase; EC=2.7.1.25; AltName: Full=3'-phosphoadenosine-5'-phosphosulfate synthase; AltName: Full=APS kinase; AltName: Full=Adenosine-5'-phosphosulfate 3'-phosphotransferase; AltName: Full=Adenylylsulfate 3'-phosphotransferase; FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. CATALYTIC ACTIVITY: ATP + sulfate = diphosphate + adenylyl sulfate. CATALYTIC ACTIVITY: ATP + adenylyl sulfate = ADP + 3'- phosphoadenylyl sulfate. ENZYME REGULATION: Inhibited by chlorate. PATHWAY: Sulfur metabolism; sulfate assimilation. TISSUE SPECIFICITY: Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. SIMILARITY: In the N-terminal section; belongs to the APS kinase family. SIMILARITY: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43252
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000103 sulfate assimilation GO:0001501 skeletal system development GO:0008152 metabolic process GO:0016310 phosphorylation GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Protein O43252 (Reactome details) participates in the following event(s):
R-HSA-174389 PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS R-HSA-174392 PAPSS1,2 transfer SO4(2-) group to ATP to form APS R-HSA-2408525 H2SeO4 is converted to APSe by PAPSS1,2 R-HSA-2408540 APSe is phosphorylated to PAPSe by PAPSS1,2 R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-174362 Transport and synthesis of PAPS R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-156584 Cytosolic sulfonation of small molecules R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-2408522 Selenoamino acid metabolism R-HSA-6802957 Oncogenic MAPK signaling R-HSA-156580 Phase II - Conjugation of compounds R-HSA-71387 Metabolism of carbohydrates R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-5663202 Diseases of signal transduction R-HSA-211859 Biological oxidations R-HSA-1430728 Metabolism R-HSA-1643685 Disease
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