Human Gene PIGZ (uc003fxh.3) Description and Page Index
Description: Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class Z (PIGZ), mRNA. RefSeq Summary (NM_025163): The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK022830.1, SRR1660805.108837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000412723.6/ ENSP00000413405.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr3:196,673,214-196,695,704 Size: 22,491 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr3:196,674,028-196,678,902 Size: 4,875 Coding Exon Count: 2
ID:PIGZ_HUMAN DESCRIPTION: RecName: Full=GPI mannosyltransferase 4; EC=2.4.1.-; AltName: Full=GPI mannosyltransferase IV; Short=GPI-MT-IV; AltName: Full=Phosphatidylinositol-glycan biosynthesis class Z protein; Short=PIG-Z; AltName: Full=SMP3 homolog; Short=hSMP3; FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed at low level, with highest level in brain and colon. SIMILARITY: Belongs to the glycosyltransferase 22 family. PIGZ subfamily. CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03901 - Alg9-like mannosyltransferase family
ModBase Predicted Comparative 3D Structure on Q86VD9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.