Description: Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 5, mRNA. RefSeq Summary (NM_001206797): This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]. Transcript (Including UTRs) Position: hg19 chr15:72,491,370-72,495,005 Size: 3,636 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr15:72,491,668-72,492,045 Size: 378 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC035487 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:4779421), with apparent retained intron. BC051346 - Homo sapiens cDNA clone IMAGE:6461886, **** WARNING: chimeric clone ****. BC035198 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:9369 IMAGE:3859987), complete cds. M26252 - Human TCB gene encoding cytosolic thyroid hormone-binding protein, complete cds. EU794631 - Homo sapiens epididymis secretory protein Li 30 (HEL-S-30) mRNA, complete cds. HZ489613 - JP 2016020328-A/13: ANTICANCER AGENT. LX088621 - JP 2017075124-A/1: DRUG SENSITIVITY ENHANCING AGENT FOR CANCER CELL, METHOD FOR PREDICTING DRUG SENSITIVITY, AND DRUG SENSITIVITY BIOMARKER. AF025439 - Homo sapiens Opa-interacting protein OIP3 mRNA, partial cds. BC019265 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:3503708), partial cds. BC023328 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:4510296). BC023592 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:4646848). BC096823 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:30558692). BC007640 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:15908 IMAGE:3533876), complete cds. BC012811 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:3932 IMAGE:2958817), complete cds. BC000481 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:8698 IMAGE:2964687), complete cds. BC094767 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:104654 IMAGE:5296639), complete cds. AK092369 - Homo sapiens cDNA FLJ35050 fis, clone OCBBF2018167, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40). AK299413 - Homo sapiens cDNA FLJ53645 complete cds, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40). BX648597 - Homo sapiens mRNA; cDNA DKFZp686G12209 (from clone DKFZp686G12209). BC007952 - Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:14360 IMAGE:4299213), complete cds. AK297951 - Homo sapiens cDNA FLJ53368 complete cds, highly similar to Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40). M23725 - Human M2-type pyruvate kinase mRNA, complete cds. JD253237 - Sequence 234261 from Patent EP1572962. JD554754 - Sequence 535778 from Patent EP1572962. AK222927 - Homo sapiens mRNA for pyruvate kinase 3 isoform 1 variant, clone: HRC08174. JD120305 - Sequence 101329 from Patent EP1572962. JD360415 - Sequence 341439 from Patent EP1572962. JD067018 - Sequence 48042 from Patent EP1572962. AK300800 - Homo sapiens cDNA FLJ54554 complete cds, highly similar to Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40). JD186650 - Sequence 167674 from Patent EP1572962. JD227184 - Sequence 208208 from Patent EP1572962. JD323231 - Sequence 304255 from Patent EP1572962. JD385499 - Sequence 366523 from Patent EP1572962. JD174331 - Sequence 155355 from Patent EP1572962. JD024294 - Sequence 5318 from Patent EP1572962. JD030195 - Sequence 11219 from Patent EP1572962. AK307855 - Homo sapiens cDNA, FLJ97803. JD026312 - Sequence 7336 from Patent EP1572962. JD403809 - Sequence 384833 from Patent EP1572962. JD021887 - Sequence 2911 from Patent EP1572962. JD029525 - Sequence 10549 from Patent EP1572962. JD391000 - Sequence 372024 from Patent EP1572962. JD540550 - Sequence 521574 from Patent EP1572962. JD540025 - Sequence 521049 from Patent EP1572962. JD042742 - Sequence 23766 from Patent EP1572962. JD047097 - Sequence 28121 from Patent EP1572962. JD326238 - Sequence 307262 from Patent EP1572962. JD131573 - Sequence 112597 from Patent EP1572962. JD369818 - Sequence 350842 from Patent EP1572962. AK294315 - Homo sapiens cDNA FLJ56065 complete cds, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40). AK309781 - Homo sapiens cDNA, FLJ99822. JD561983 - Sequence 543007 from Patent EP1572962. EU832358 - Synthetic construct Homo sapiens clone HAIB:100067387; DKFZo008H1227 pyruvate kinase, muscle protein (PKM2) gene, encodes complete protein. AK312253 - Homo sapiens cDNA, FLJ92548, highly similar to Homo sapiens pyruvate kinase, muscle (PKM2), mRNA. KJ891817 - Synthetic construct Homo sapiens clone ccsbBroadEn_01211 PKM2 gene, encodes complete protein. KJ905271 - Synthetic construct Homo sapiens clone ccsbBroadEn_14768 PKM2 gene, encodes complete protein. KR710112 - Synthetic construct Homo sapiens clone CCSBHm_00009784 PKM (PKM) mRNA, encodes complete protein. KR710113 - Synthetic construct Homo sapiens clone CCSBHm_00009785 PKM (PKM) mRNA, encodes complete protein. EU832443 - Synthetic construct Homo sapiens clone HAIB:100067472; DKFZo004H1228 pyruvate kinase, muscle protein (PKM2) gene, encodes complete protein. DQ892739 - Synthetic construct clone IMAGE:100005369; FLH189257.01X; RZPDo839D0374D pyruvate kinase, muscle (PKM2) gene, encodes complete protein. EU176742 - Synthetic construct Homo sapiens clone IMAGE:100011510; FLH189256.01L; RZPDo839G10255D pyruvate kinase, muscle (PKM2) gene, encodes complete protein. AB528306 - Synthetic construct DNA, clone: pF1KB9947, Homo sapiens PKM2 gene for pyruvate kinase, muscle, without stop codon, in Flexi system. HZ473969 - WO 2016002844-A/83: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. AK308264 - Homo sapiens cDNA, FLJ98212. HZ489614 - JP 2016020328-A/14: ANTICANCER AGENT. JD022966 - Sequence 3990 from Patent EP1572962. JD022355 - Sequence 3379 from Patent EP1572962. JD027715 - Sequence 8739 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00010 - Glycolysis / Gluconeogenesis hsa00230 - Purine metabolism hsa00620 - Pyruvate metabolism hsa01100 - Metabolic pathways hsa04930 - Type II diabetes mellitus