Human Gene PPWD1 (uc003jtv.5) Description and Page Index
  Description: Homo sapiens peptidylprolyl isomerase domain and WD repeat containing 1 (PPWD1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:64,859,063-64,883,376 Size: 24,314 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr5:64,859,138-64,883,223 Size: 24,086 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:64,859,063-64,883,376)mRNA (may differ from genome)Protein (646 aa)
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-  Comments and Description Text from UniProtKB
  ID: PPWD1_HUMAN
DESCRIPTION: RecName: Full=Peptidylprolyl isomerase domain and WD repeat-containing protein 1; EC=5.2.1.8; AltName: Full=Spliceosome-associated cyclophilin;
FUNCTION: Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBUNIT: Identified in the spliceosome C complex.
SUBCELLULAR LOCATION: Nucleus. Note=Associated with spliceosomal complexes.
SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.
SIMILARITY: Contains 4 WD repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.02 RPKM in Spleen
Total median expression: 641.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.7075-0.276 Picture PostScript Text
3' UTR -20.90153-0.137 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50891 - Cyclophilin-like
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2A2N
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96BP3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016018 cyclosporin A binding
GO:0016853 isomerase activity

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006397 mRNA processing
GO:0008380 RNA splicing

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016604 nuclear body
GO:0071013 catalytic step 2 spliceosome


-  Descriptions from all associated GenBank mRNAs
  LF209896 - JP 2014500723-A/17399: Polycomb-Associated Non-Coding RNAs.
AK025679 - Homo sapiens cDNA: FLJ22026 fis, clone HEP08537.
AK300022 - Homo sapiens cDNA FLJ53187 complete cds, highly similar to Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).
AK301654 - Homo sapiens cDNA FLJ53227 complete cds, highly similar to Peptidylprolyl isomerase domain and WDrepeat-containing protein 1 (EC 5.2.1.8).
AK298175 - Homo sapiens cDNA FLJ53149 complete cds, highly similar to Peptidylprolyl isomerase domain and WDrepeat-containing protein 1 (EC 5.2.1.8).
BC015385 - Homo sapiens peptidylprolyl isomerase domain and WD repeat containing 1, mRNA (cDNA clone MGC:21685 IMAGE:4390706), complete cds.
GQ891478 - Homo sapiens clone HEL-S-199 epididymis secretory sperm binding protein mRNA, complete cds.
AB384434 - Synthetic construct DNA, clone: pF1KA0073, Homo sapiens PPWD1 gene for peptidylprolyl isomerase domain and WD repeat-containing protein 1, complete cds, without stop codon, in Flexi system.
GQ129262 - Synthetic construct Homo sapiens clone HAIB:100068663; DKFZo004C0136 peptidylprolyl isomerase domain and WD repeat containing 1 protein (PPWD1) gene, partial cds.
GQ129263 - Synthetic construct Homo sapiens clone HAIB:100068566; DKFZo008C0135 peptidylprolyl isomerase domain and WD repeat containing 1 protein (PPWD1) gene, complete cds.
KJ898483 - Synthetic construct Homo sapiens clone ccsbBroadEn_07877 PPWD1 gene, encodes complete protein.
D38552 - Homo sapiens KIAA0073 mRNA, partial cds.
MA445473 - JP 2018138019-A/17399: Polycomb-Associated Non-Coding RNAs.
AK093675 - Homo sapiens cDNA FLJ36356 fis, clone THYMU2007415.
CU677289 - Synthetic construct Homo sapiens gateway clone IMAGE:100020763 5' read PPWD1 mRNA.
LF332513 - JP 2014500723-A/140016: Polycomb-Associated Non-Coding RNAs.
LF332508 - JP 2014500723-A/140011: Polycomb-Associated Non-Coding RNAs.
MA568090 - JP 2018138019-A/140016: Polycomb-Associated Non-Coding RNAs.
MA568085 - JP 2018138019-A/140011: Polycomb-Associated Non-Coding RNAs.
AK057718 - Homo sapiens cDNA FLJ33156 fis, clone UTERU2000377, weakly similar to PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C57A10.03 (EC 5.2.1.8).
LF332506 - JP 2014500723-A/140009: Polycomb-Associated Non-Coding RNAs.
MA568083 - JP 2018138019-A/140009: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96BP3 (Reactome details) participates in the following event(s):

R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0073, NM_015342, NP_056157, PPWD1_HUMAN, Q15002, Q7KZ89, Q96BP3, uc003jtv.4
UCSC ID: uc003jtv.5
RefSeq Accession: NM_015342
Protein: Q96BP3 (aka PPWD1_HUMAN)
CCDS: CCDS3985.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015342.3
exon count: 11CDS single in 3' UTR: no RNA size: 2186
ORF size: 1941CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4071.00frame shift in genome: no % Coverage: 99.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.