Human Gene PRKCA (uc002jfp.1) Description and Page Index
  Description: Homo sapiens protein kinase C, alpha (PRKCA), mRNA.
RefSeq Summary (NM_002737): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.10531.1, SRR1660807.61550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000413366.8/ ENSP00000408695.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr17:64,298,926-64,806,862 Size: 507,937 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr17:64,298,970-64,800,155 Size: 501,186 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:64,298,926-64,806,862)mRNA (may differ from genome)Protein (672 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KPCA_HUMAN
DESCRIPTION: RecName: Full=Protein kinase C alpha type; Short=PKC-A; Short=PKC-alpha; EC=2.7.11.13;
FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)- dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B- ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF- kappa-B-induced genes, through IL1A-dependent induction of NF- kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O- tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
ENZYME REGULATION: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation.
SUBUNIT: Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1 (By similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. Interacts with PICK1 (via PDZ domain). Interacts with TRIM41.
INTERACTION: Q24008:inaD (xeno); NbExp=2; IntAct=EBI-1383528, EBI-195326; P31431:SDC4; NbExp=2; IntAct=EBI-1383528, EBI-3913237;
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein (Probable). Nucleus.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
SIMILARITY: Contains 1 C2 domain.
SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers.
SIMILARITY: Contains 1 protein kinase domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRKCA
CDC HuGE Published Literature: PRKCA
Positive Disease Associations: Alcoholism , Body Height , Cholesterol , Cholesterol, LDL , Diabetes Mellitus, Type 2 , Heart Function Tests , multiple sclerosis , Pancreatic Neoplasms , Tunica Media
Related Studies:
  1. Alcoholism
    , , . [PubMed 0]
  2. Body Height
    Cara L Carty et al. Human molecular genetics 2012, Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)., Human molecular genetics. [PubMed 22021425]
  3. Cholesterol
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PRKCA
Diseases sorted by gene-association score: renal artery atheroma (16), glioma (14), asbestos-related lung carcinoma (11), retinitis pigmentosa 38 (11), glioblastoma (11), myotonic dystrophy 1 (8), polycystic kidney disease 1 (6), lung cancer (3), breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.40 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 315.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.0044-0.341 Picture PostScript Text
3' UTR -2266.186707-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000961 - AGC-kinase_C
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR020477 - C2_dom
IPR018029 - C2_membr_targeting
IPR020454 - DAG/PE-bd
IPR011009 - Kinase-like_dom
IPR017892 - Pkinase_C
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR014375 - Protein_kinase_C_a/b/g
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF00130 - Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00168 - C2 domain
PF00433 - Protein kinase C terminal domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56112 - Protein kinase-like (PK-like)
57889 - Cysteine-rich domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2ELI
- NMR MuPIT

3IW4
- X-ray MuPIT

4DNL
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P17252
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0035403 histone kinase activity (H3-T6 specific)
GO:0046872 metal ion binding

Biological Process:
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002159 desmosome assembly
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007077 mitotic nuclear envelope disassembly
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035408 histone H3-T6 phosphorylation
GO:0035556 intracellular signal transduction
GO:0038128 ERBB2 signaling pathway
GO:0043488 regulation of mRNA stability
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045651 positive regulation of macrophage differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0045931 positive regulation of mitotic cell cycle
GO:0050796 regulation of insulin secretion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0090330 regulation of platelet aggregation
GO:0097190 apoptotic signaling pathway
GO:2000707 positive regulation of dense core granule biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC053321 - Homo sapiens protein kinase C, alpha, mRNA (cDNA clone IMAGE:6538304), partial cds.
X52479 - Human PKC alpha mRNA for protein kinase C alpha.
BC109273 - Homo sapiens protein kinase C, alpha, mRNA (cDNA clone MGC:129900 IMAGE:40028305), complete cds.
BC109274 - Homo sapiens protein kinase C, alpha, mRNA (cDNA clone MGC:129901 IMAGE:40028308), complete cds.
AY633609 - Homo sapiens aging-associated gene 6 protein mRNA, complete cds.
KJ891887 - Synthetic construct Homo sapiens clone ccsbBroadEn_01281 PRKCA gene, encodes complete protein.
GQ129311 - Synthetic construct Homo sapiens clone HAIB:100068458; DKFZo004A1134 protein kinase C, alpha protein (PRKCA) gene, partial cds.
EU832768 - Synthetic construct Homo sapiens clone HAIB:100067797; DKFZo008A1133 protein kinase C, alpha protein (PRKCA) gene, encodes complete protein.
AB527684 - Synthetic construct DNA, clone: pF1KB6227, Homo sapiens PRKCA gene for protein kinase C, alpha, without stop codon, in Flexi system.
AB451383 - Homo sapiens PRKCA mRNA for protein kinase C alpha type, partial cds, clone: FLJ08071AAAF.
AB451258 - Homo sapiens PRKCA mRNA for protein kinase C alpha type, complete cds, clone: FLJ08071AAAN.
LC151409 - Homo sapiens PRKCA mRNA for protein kinase C alpha, complete cds.
AB209475 - Homo sapiens mRNA for protein kinase C, alpha variant protein.
M22199 - Human protein kinase C alpha-polypeptide (PKCA) mRNA, partial cds.
DD356917 - Method of Screening for Compound Regulating Translation of Specific mRNA.
AK098118 - Homo sapiens cDNA FLJ40799 fis, clone TRACH2007988.
JD284416 - Sequence 265440 from Patent EP1572962.
AF035594 - Homo sapiens protein kinase C-alpha mRNA, partial 3' UTR.
JD077924 - Sequence 58948 from Patent EP1572962.
BX648954 - Homo sapiens mRNA; cDNA DKFZp686I0348 (from clone DKFZp686I0348).
AF035595 - Homo sapiens protein kinase C-alpha mRNA, partial 3' UTR.
DQ588097 - Homo sapiens piRNA piR-55209, complete sequence.
BC101403 - Homo sapiens cDNA clone IMAGE:40001378.
BC103691 - Homo sapiens cDNA clone IMAGE:40001373.
BC107592 - Homo sapiens cDNA clone IMAGE:40001372.
BC122530 - Homo sapiens cDNA clone IMAGE:40011687.
AF086287 - Homo sapiens full length insert cDNA clone ZD48A02.
AK125425 - Homo sapiens cDNA FLJ43436 fis, clone OCBBF2028935.
JD193794 - Sequence 174818 from Patent EP1572962.
JD536011 - Sequence 517035 from Patent EP1572962.
JD453787 - Sequence 434811 from Patent EP1572962.
JD200852 - Sequence 181876 from Patent EP1572962.
JD554664 - Sequence 535688 from Patent EP1572962.
JD252747 - Sequence 233771 from Patent EP1572962.
JD200959 - Sequence 181983 from Patent EP1572962.
AK055431 - Homo sapiens cDNA FLJ30869 fis, clone FEBRA2004224.
BC015855 - Homo sapiens protein kinase C, alpha, mRNA (cDNA clone IMAGE:4668430), with apparent retained intron.
JD250714 - Sequence 231738 from Patent EP1572962.
JD451255 - Sequence 432279 from Patent EP1572962.
JD351027 - Sequence 332051 from Patent EP1572962.
JD077786 - Sequence 58810 from Patent EP1572962.
JD068855 - Sequence 49879 from Patent EP1572962.
JD263952 - Sequence 244976 from Patent EP1572962.
JD491908 - Sequence 472932 from Patent EP1572962.
JD262542 - Sequence 243566 from Patent EP1572962.
JD166186 - Sequence 147210 from Patent EP1572962.
JD562181 - Sequence 543205 from Patent EP1572962.
JD293413 - Sequence 274437 from Patent EP1572962.
JD119401 - Sequence 100425 from Patent EP1572962.
JD538378 - Sequence 519402 from Patent EP1572962.
JD069848 - Sequence 50872 from Patent EP1572962.
JD069847 - Sequence 50871 from Patent EP1572962.
JD069846 - Sequence 50870 from Patent EP1572962.
JD381290 - Sequence 362314 from Patent EP1572962.
JD381291 - Sequence 362315 from Patent EP1572962.
JD322889 - Sequence 303913 from Patent EP1572962.
JD058818 - Sequence 39842 from Patent EP1572962.
JD074154 - Sequence 55178 from Patent EP1572962.
JD488486 - Sequence 469510 from Patent EP1572962.
BC071767 - Homo sapiens cDNA clone IMAGE:4093617, partial cds.
JD106825 - Sequence 87849 from Patent EP1572962.
JD378874 - Sequence 359898 from Patent EP1572962.
JD469620 - Sequence 450644 from Patent EP1572962.
JD285965 - Sequence 266989 from Patent EP1572962.
JD240215 - Sequence 221239 from Patent EP1572962.
BC062759 - Homo sapiens protein kinase C, alpha, mRNA (cDNA clone IMAGE:4093756), partial cds.
JD491594 - Sequence 472618 from Patent EP1572962.
JD491595 - Sequence 472619 from Patent EP1572962.
JD044636 - Sequence 25660 from Patent EP1572962.
JD389709 - Sequence 370733 from Patent EP1572962.
JD362819 - Sequence 343843 from Patent EP1572962.
JD288297 - Sequence 269321 from Patent EP1572962.
JD410321 - Sequence 391345 from Patent EP1572962.
JD088903 - Sequence 69927 from Patent EP1572962.
JD184500 - Sequence 165524 from Patent EP1572962.
JD065793 - Sequence 46817 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04020 - Calcium signaling pathway
hsa04070 - Phosphatidylinositol signaling system
hsa04270 - Vascular smooth muscle contraction
hsa04310 - Wnt signaling pathway
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04530 - Tight junction
hsa04540 - Gap junction
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04670 - Leukocyte transendothelial migration
hsa04720 - Long-term potentiation
hsa04730 - Long-term depression
hsa04912 - GnRH signaling pathway
hsa04916 - Melanogenesis
hsa04960 - Aldosterone-regulated sodium reabsorption
hsa05110 - Vibrio cholerae infection
hsa05130 - Pathogenic Escherichia coli infection
hsa05200 - Pathways in cancer
hsa05214 - Glioma
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_bcrPathway - BCR Signaling Pathway
h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation
h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage
h_edg1Pathway - Phospholipids as signalling intermediaries
h_ghPathway - Growth Hormone Signaling Pathway
h_plcPathway - Phospholipase C Signaling Pathway
h_plcdPathway - Phospholipase C d1 in phospholipid associated cell signaling
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_ionPathway - Ion Channel and Phorbal Esters Signaling Pathway
h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_agpcrPathway - Attenuation of GPCR Signaling
h_egfPathway - EGF Signaling Pathway
h_pkcPathway - Activation of PKC through G protein coupled receptor
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_tcrPathway - T Cell Receptor Signaling Pathway
h_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors
h_erbB4pathway - g-Secretase mediated ErbB4 Signaling Pathway
h_trkaPathway - Trka Receptor Signaling Pathway
h_Par1Pathway - Thrombin signaling and protease-activated receptors
h_crebPathway - Transcription factor CREB and its extracellular signals
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_TPOPathway - TPO Signaling Pathway
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_mef2dPathway - Role of MEF2D in T-cell Apoptosis
h_keratinocytePathway - Keratinocyte Differentiation
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2
h_myosinPathway - PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
h_nos1Pathway - Nitric Oxide Signaling Pathway
h_pdgfPathway - PDGF Signaling Pathway
h_srcRPTPPathway - Activation of Src by Protein-tyrosine phosphatase alpha

Reactome (by CSHL, EBI, and GO)

Protein P17252 (Reactome details) participates in the following event(s):

R-HSA-400015 Diacylgycerol activates Protein kinase C, alpha type
R-HSA-1433508 PKC alpha interacts with and phosphorylates KIT
R-HSA-4332390 Translocation and activation of PKC alpha in response to WNT signaling
R-HSA-9010643 AKAP5 recruits PKC to ROBO2
R-HSA-9010646 AKAP5 recruits PKC to ROBO3.1
R-HSA-2750187 Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG
R-HSA-114553 Activation of conventional Protein Kinase C
R-HSA-5218821 PDK1 phosphorylates PKC
R-HSA-8855915 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors
R-HSA-450550 PKCalpha phosphorylates HuR
R-HSA-9010681 PKC phosphorylates ROBO3.1
R-HSA-5218813 DAG and Ca+2 bind to PKC and tether it to membrane
R-HSA-5218805 PKC autophosphorylates
R-HSA-5223304 DAG and Ca+2 bind to PKC and tether it to membrane
R-HSA-399978 Protein kinase C, alpha type phosphorylates MARCKS
R-HSA-74615 PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP
R-HSA-111970 PKC phosphorylates GRK2
R-HSA-8982703 PKC binds active G alpha (z)
R-HSA-8982709 G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
R-HSA-114683 Phosphorylation of Platelet Sec-1
R-HSA-114684 Phosphorylation of Syntaxin-4
R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors
R-HSA-5138432 DVL2 is phosphorylated by PKC
R-HSA-5218823 PKC phosphorylates sphingosine kinase 1
R-HSA-8934446 Activated PKC phosphorylates SHC1
R-HSA-751040 PKC phosphorylates G alpha (z)
R-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-1433559 Regulation of KIT signaling
R-HSA-4086398 Ca2+ pathway
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-3000170 Syndecan interactions
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-8853659 RET signaling
R-HSA-422356 Regulation of insulin secretion
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-4419969 Depolymerisation of the Nuclear Lamina
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-422475 Axon guidance
R-HSA-163685 Energy Metabolism
R-HSA-416476 G alpha (q) signalling events
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-195721 Signaling by WNT
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-1474244 Extracellular matrix organization
R-HSA-111933 Calmodulin induced events
R-HSA-109582 Hemostasis
R-HSA-194138 Signaling by VEGF
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-388396 GPCR downstream signalling
R-HSA-162582 Signal Transduction
R-HSA-418597 G alpha (z) signalling events
R-HSA-114516 Disinhibition of SNARE formation
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-8953854 Metabolism of RNA
R-HSA-2514856 The phototransduction cascade
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-68875 Mitotic Prophase
R-HSA-111997 CaM pathway
R-HSA-372790 Signaling by GPCR
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-4086400 PCP/CE pathway
R-HSA-2187338 Visual phototransduction
R-HSA-1227986 Signaling by ERBB2
R-HSA-68886 M Phase
R-HSA-111996 Ca-dependent events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-418594 G alpha (i) signalling events
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-112043 PLC beta mediated events
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-1640170 Cell Cycle
R-HSA-112040 G-protein mediated events
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-111885 Opioid Signalling
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: B5BU22, KPCA_HUMAN, NM_002737, NP_002728, P17252, PKCA, PRKACA, Q15137, Q32M72, Q96RE4
UCSC ID: uc002jfp.1
RefSeq Accession: NM_002737
Protein: P17252 (aka KPCA_HUMAN)
CCDS: CCDS11664.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002737.2
exon count: 17CDS single in 3' UTR: no RNA size: 8787
ORF size: 2019CDS single in intron: no Alignment % ID: 99.98
txCdsPredict score: 4238.00frame shift in genome: no % Coverage: 99.81
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.