Description: Homo sapiens proteasome (prosome, macropain) inhibitor subunit 1 (PI31) (PSMF1), transcript variant 1, mRNA. RefSeq Summary (NM_006814): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:1,099,240-1,148,426 Size: 49,187 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr20:1,099,417-1,145,724 Size: 46,308 Coding Exon Count: 7
ID:PSMF1_HUMAN DESCRIPTION: RecName: Full=Proteasome inhibitor PI31 subunit; Short=hPI31; FUNCTION: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. SUBUNIT: Monomer (Probable). INTERACTION: Q9NWB1:RBFOX1; NbExp=2; IntAct=EBI-945916, EBI-945906; SIMILARITY: Belongs to the proteasome inhibitor PI31 family.
Hemoglobin A, Glycosylated Andrew D Paterson et al. Diabetes 2010, A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose., Diabetes.
[PubMed 19875614]
A major locus for A1C and glucose in individuals with diabetes is near SORCS1. This may influence the design and analysis of genetic studies attempting to identify risk factors for long-term diabetic complications.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92530
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004866 endopeptidase inhibitor activity GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity GO:0070628 proteasome binding
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0010951 negative regulation of endopeptidase activity GO:0016579 protein deubiquitination GO:0043687 post-translational protein modification GO:1901799 negative regulation of proteasomal protein catabolic process