Description: Homo sapiens solute carrier family 18 (vesicular acetylcholine), member 3 (SLC18A3), mRNA. RefSeq Summary (NM_003055): This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr10:50,818,347-50,820,766 Size: 2,420 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr10:50,818,787-50,820,385 Size: 1,599 Coding Exon Count: 1
ID:VACHT_HUMAN DESCRIPTION: RecName: Full=Vesicular acetylcholine transporter; Short=VAChT; AltName: Full=Solute carrier family 18 member 3; FUNCTION: Involved in acetylcholine transport into synaptic vesicles. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Peripheral and central cholinergic nervous systems. SIMILARITY: Belongs to the major facilitator superfamily. Vesicular transporter family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q16572
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U09210 - Human vesicular acetylcholine transporter mRNA, complete cds. BC007765 - Homo sapiens solute carrier family 18 (vesicular acetylcholine), member 3, mRNA (cDNA clone MGC:12716 IMAGE:4136084), complete cds. JD133362 - Sequence 114386 from Patent EP1572962. AK313094 - Homo sapiens cDNA, FLJ93577, Homo sapiens solute carrier family 18 (vesicular acetylcholine),member 3 (SLC18A3), mRNA. JD457718 - Sequence 438742 from Patent EP1572962. JD125532 - Sequence 106556 from Patent EP1572962. CU675799 - Synthetic construct Homo sapiens gateway clone IMAGE:100019802 5' read SLC18A3 mRNA. JF432245 - Synthetic construct Homo sapiens clone IMAGE:100073412 solute carrier family 18 (vesicular acetylcholine), member 3 (SLC18A3) gene, encodes complete protein. KJ897576 - Synthetic construct Homo sapiens clone ccsbBroadEn_06970 SLC18A3 gene, encodes complete protein. JD463570 - Sequence 444594 from Patent EP1572962. JD463571 - Sequence 444595 from Patent EP1572962. JD398132 - Sequence 379156 from Patent EP1572962. JD136651 - Sequence 117675 from Patent EP1572962. JD500190 - Sequence 481214 from Patent EP1572962. JD110665 - Sequence 91689 from Patent EP1572962. JD117378 - Sequence 98402 from Patent EP1572962. JD065516 - Sequence 46540 from Patent EP1572962. JD136945 - Sequence 117969 from Patent EP1572962. JD070901 - Sequence 51925 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q16572 (Reactome details) participates in the following event(s):
R-HSA-372529 Release of acetylcholine at the synapse R-HSA-264615 Loading of acetylcholine in synaptic vesicle R-HSA-372505 Acetylcholine synaptic vesicle docking and priming R-HSA-8866277 AP-2 directly binds some endocytic cargo R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit R-HSA-8868071 Clathrin recruits PIK3C2A R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle R-HSA-112310 Neurotransmitter release cycle R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-112315 Transmission across Chemical Synapses R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-112316 Neuronal System R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
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