Description: Homo sapiens solute carrier family 22 (extraneuronal monoamine transporter), member 3 (SLC22A3), mRNA. RefSeq Summary (NM_021977): Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:160,769,405-160,873,611 Size: 104,207 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr6:160,769,452-160,872,088 Size: 102,637 Coding Exon Count: 11
ID:S22A3_HUMAN DESCRIPTION: RecName: Full=Solute carrier family 22 member 3; AltName: Full=Extraneuronal monoamine transporter; Short=EMT; AltName: Full=Organic cation transporter 3; FUNCTION: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. INTERACTION: P00519:ABL1; NbExp=2; IntAct=EBI-1752674, EBI-375543; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Colonic Neoplasms R Cui et al. Gut 2011, Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population., Gut.
[PubMed 21242260]
We found a novel susceptible locus in SLC22A3 that contributes to the risk of distal colon cancer in an Asian population. These findings would further extend our understanding of the role of common genetic variants in the aetiology of CRC.
Colony-Forming Units Assay Stanley Y Shaw et al. Circulation. Cardiovascular genetics 2011, Genetic and clinical correlates of early-outgrowth colony-forming units., Circulation. Cardiovascular genetics.
[PubMed 21493818]
In a community-based sample, early-outgrowth CFUs are inversely associated with select cardiovascular risk factors. Furthermore, genetic variants at the SLC22A3-LPAL2-LPA locus are associated with both decreased CFUs and an increased risk of myocardial infarction. These findings are consistent with the hypothesis that decreased circulating angiogenic cell populations promote susceptibility to myocardial infarction.
coronary artery disease Tregouet ,et al. 2009, Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease, Nature genetics 2009 41- 3 : 283-5.
[PubMed 19198611]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on O75751
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC144280 - Homo sapiens cDNA clone IMAGE:9052800. AK314590 - Homo sapiens cDNA, FLJ95424, Homo sapiens solute carrier family 22 (extraneuronal monoaminetransporter), member 3 (SLC22A3), mRNA. AJ001417 - Homo sapiens mRNA for extraneuronal monoamine transporter. BC156538 - Synthetic construct Homo sapiens clone IMAGE:100063252, MGC:190724 solute carrier family 22 (extraneuronal monoamine transporter), member 3 (SLC22A3) mRNA, encodes complete protein. BC172500 - Synthetic construct Homo sapiens clone IMAGE:100069194, MGC:199205 solute carrier family 22 (extraneuronal monoamine transporter), member 3 (SLC22A3) mRNA, encodes complete protein. JD408543 - Sequence 389567 from Patent EP1572962. BX640965 - Homo sapiens mRNA; cDNA DKFZp686N10184 (from clone DKFZp686N10184). AF078749 - Homo sapiens organic cation transporter 3 (SLC22A3) mRNA, partial cds. AK125826 - Homo sapiens cDNA FLJ43838 fis, clone TESTI4006053. JD448034 - Sequence 429058 from Patent EP1572962. JD282228 - Sequence 263252 from Patent EP1572962. JD195496 - Sequence 176520 from Patent EP1572962. JD058419 - Sequence 39443 from Patent EP1572962. JD239174 - Sequence 220198 from Patent EP1572962. JD305644 - Sequence 286668 from Patent EP1572962. JD452113 - Sequence 433137 from Patent EP1572962. JD089690 - Sequence 70714 from Patent EP1572962. BC070300 - Homo sapiens cDNA clone IMAGE:4716887, partial cds. JD046881 - Sequence 27905 from Patent EP1572962. JD088928 - Sequence 69952 from Patent EP1572962. JD468526 - Sequence 449550 from Patent EP1572962. JD204428 - Sequence 185452 from Patent EP1572962. JD078894 - Sequence 59918 from Patent EP1572962. AK096980 - Homo sapiens cDNA FLJ39661 fis, clone SMINT2007101. JD053127 - Sequence 34151 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75751 (Reactome details) participates in the following event(s):
R-HSA-549304 OCT3 mediates renal clearance of organic cations R-HSA-561072 OCT3 mediates renal uptake of organic cations R-HSA-2161500 abacavir [extracellular] => abacavir [cytosol] R-HSA-549127 Organic cation transport R-HSA-2161517 Abacavir transmembrane transport R-HSA-549132 Organic cation/anion/zwitterion transport R-HSA-2161522 Abacavir transport and metabolism R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-1430728 Metabolism R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules