Human Gene SLC45A3 (uc001hda.1)
  Description: Homo sapiens solute carrier family 45, member 3 (SLC45A3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:205,626,981-205,649,630 Size: 22,650 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:205,628,362-205,633,784 Size: 5,423 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:205,626,981-205,649,630)mRNA (may differ from genome)Protein (553 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Solute carrier family 45 member 3; AltName: Full=Prostate cancer-associated protein 6; AltName: Full=Prostein;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.
INDUCTION: Up-regulated by androgens.
MISCELLANEOUS: Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas- directed cytotoxic T-cell lymphocytes.
SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC45A3
CDC HuGE Published Literature: SLC45A3
Positive Disease Associations: Asthma , Neutrophils , Parkinson's disease
Related Studies:
  1. Asthma
    Medea Imboden et al. The Journal of allergy and clinical immunology 2012, Genome-wide association study of lung function decline in adults with and without asthma., The Journal of allergy and clinical immunology. [PubMed 22424883]
    Genetic heterogeneity of lung function might be extensive. Our results suggest that genetic determinants of longitudinal and cross-sectional lung function differ and vary by asthma status.
  2. Neutrophils
    Yukinori Okada et al. PLoS genetics 2011, Identification of nine novel loci associated with white blood cell subtypes in a Japanese population., PLoS genetics. [PubMed 21738478]
  3. Parkinson's disease
    Satake ,et al. 2009, Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease, Nature genetics 2009 41- 12 : 1303-7. [PubMed 19915576]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC45A3
Diseases sorted by gene-association score: prostate cancer (5), male reproductive organ cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 113.83 RPKM in Prostate
Total median expression: 272.63 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -143.80339-0.424 Picture PostScript Text
3' UTR -493.021381-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011701 - MFS
IPR016196 - MFS_dom_general_subst_transpt

Pfam Domains:
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q96JT2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008506 sucrose:proton symporter activity
GO:0051119 sugar transmembrane transporter activity

Biological Process:
GO:0008645 hexose transport
GO:0010907 positive regulation of glucose metabolic process
GO:0015770 sucrose transport
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0048713 regulation of oligodendrocyte differentiation
GO:0055085 transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  EF632109 - Homo sapiens SLC45A3/ETV1 fusion transcript mRNA, partial sequence.
FJ805262 - Homo sapiens SLC45A3-ELK4 transcript variant 5 mRNA sequence.
FJ805258 - Homo sapiens SLC45A3-ELK4 transcript variant 1 mRNA sequence.
FJ805259 - Homo sapiens SLC45A3-ELK4 transcript variant 2 mRNA sequence.
FJ805260 - Homo sapiens SLC45A3-ELK4 transcript variant 3 mRNA sequence.
FJ805261 - Homo sapiens SLC45A3-ELK4 transcript variant 4 mRNA sequence.
AL832933 - Homo sapiens mRNA; cDNA DKFZp666D0110 (from clone DKFZp666D0110).
AY033593 - Homo sapiens prostein mRNA, complete cds.
BC050416 - Homo sapiens solute carrier family 45, member 3, mRNA (cDNA clone MGC:54090 IMAGE:6198823), complete cds.
JD404071 - Sequence 385095 from Patent EP1572962.
JD538390 - Sequence 519414 from Patent EP1572962.
JD470850 - Sequence 451874 from Patent EP1572962.
JD554826 - Sequence 535850 from Patent EP1572962.
JD326491 - Sequence 307515 from Patent EP1572962.
JD078137 - Sequence 59161 from Patent EP1572962.
JD381274 - Sequence 362298 from Patent EP1572962.
JD354805 - Sequence 335829 from Patent EP1572962.
JD503611 - Sequence 484635 from Patent EP1572962.
JD250519 - Sequence 231543 from Patent EP1572962.
JD436467 - Sequence 417491 from Patent EP1572962.
JD428911 - Sequence 409935 from Patent EP1572962.
JD122624 - Sequence 103648 from Patent EP1572962.
JD324572 - Sequence 305596 from Patent EP1572962.
AK290364 - Homo sapiens cDNA FLJ77976 complete cds, highly similar to Homo sapiens prostein mRNA.
JD375427 - Sequence 356451 from Patent EP1572962.
JD076163 - Sequence 57187 from Patent EP1572962.
JD179888 - Sequence 160912 from Patent EP1572962.
JD217757 - Sequence 198781 from Patent EP1572962.
JD485181 - Sequence 466205 from Patent EP1572962.
JD072492 - Sequence 53516 from Patent EP1572962.
JD366098 - Sequence 347122 from Patent EP1572962.
JD159370 - Sequence 140394 from Patent EP1572962.
JD142756 - Sequence 123780 from Patent EP1572962.
AK313479 - Homo sapiens cDNA, FLJ94027, Homo sapiens prostein protein (Prostein), mRNA.
KJ899869 - Synthetic construct Homo sapiens clone ccsbBroadEn_09263 SLC45A3 gene, encodes complete protein.
JD336126 - Sequence 317150 from Patent EP1572962.
JD290925 - Sequence 271949 from Patent EP1572962.
JD441624 - Sequence 422648 from Patent EP1572962.
JD461714 - Sequence 442738 from Patent EP1572962.
JD111923 - Sequence 92947 from Patent EP1572962.
JD059423 - Sequence 40447 from Patent EP1572962.
JD386673 - Sequence 367697 from Patent EP1572962.
JD441825 - Sequence 422849 from Patent EP1572962.
JD134621 - Sequence 115645 from Patent EP1572962.
JD203292 - Sequence 184316 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96JT2 (Reactome details) participates in the following event(s):

R-HSA-8875902 SLC45A3 transports Glc from extracellular region to cytosol
R-HSA-189200 Cellular hexose transport
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: NM_033102, NP_149093, PCANAP6, PRST, Q96JT2, S45A3_HUMAN
UCSC ID: uc001hda.1
RefSeq Accession: NM_033102
Protein: Q96JT2 (aka S45A3_HUMAN)
CCDS: CCDS1458.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_033102.2
exon count: 5CDS single in 3' UTR: no RNA size: 3398
ORF size: 1662CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3371.00frame shift in genome: no % Coverage: 99.53
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.