Description: Homo sapiens smoothened, frizzled family receptor (SMO), mRNA. RefSeq Summary (NM_005631): The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr7:128,828,713-128,853,385 Size: 24,673 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr7:128,828,993-128,852,292 Size: 23,300 Coding Exon Count: 12
ID:SMO_HUMAN DESCRIPTION: RecName: Full=Smoothened homolog; Short=SMO; AltName: Full=Protein Gx; Flags: Precursor; FUNCTION: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. SUBUNIT: Interacts with ARRB2 (By similarity). Interacts with KIF7. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. SIMILARITY: Contains 1 FZ (frizzled) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99835
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.