Human Gene STRN3 (uc001wqu.2)
  Description: Homo sapiens striatin, calmodulin binding protein 3 (STRN3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:31,363,005-31,495,607 Size: 132,603 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr14:31,364,617-31,495,391 Size: 130,775 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:31,363,005-31,495,607)mRNA (may differ from genome)Protein (797 aa)
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-  Comments and Description Text from UniProtKB
  ID: STRN3_HUMAN
DESCRIPTION: RecName: Full=Striatin-3; AltName: Full=Cell cycle autoantigen SG2NA; AltName: Full=S/G2 antigen;
FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
SUBUNIT: Interacts with protein phosphatase 2A (PP2A) (Potential).
INTERACTION: Q9P2B4:CTTNBP2NL; NbExp=4; IntAct=EBI-1053857, EBI-1774273; O43815:STRN; NbExp=4; IntAct=EBI-1053857, EBI-1046642; Q9Y228:TRAF3IP3; NbExp=2; IntAct=EBI-1053857, EBI-765817;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the WD repeat striatin family.
SIMILARITY: Contains 6 WD repeats.
CAUTION: Was originally (PubMed:7864889) thought to be nuclear.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STRN3
CDC HuGE Published Literature: STRN3
Positive Disease Associations: Heart Failure
Related Studies:
  1. Heart Failure
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.41 RPKM in Muscle - Skeletal
Total median expression: 204.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -97.62216-0.452 Picture PostScript Text
3' UTR -373.181612-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR013258 - Striatin_N
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF08232 - Striatin family

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q13033
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0017048 Rho GTPase binding
GO:0044877 macromolecular complex binding
GO:0051721 protein phosphatase 2A binding
GO:0070016 armadillo repeat domain binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0032355 response to estradiol
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0032991 macromolecular complex
GO:0043025 neuronal cell body
GO:0000159 protein phosphatase type 2A complex


-  Descriptions from all associated GenBank mRNAs
  U17989 - Homo sapiens nuclear autoantigen GS2NA mRNA, complete cds.
AK290229 - Homo sapiens cDNA FLJ77970 complete cds, highly similar to Homo sapiens nuclear autoantigen GS2NA mRNA.
BC126221 - Homo sapiens striatin, calmodulin binding protein 3, mRNA (cDNA clone MGC:161499 IMAGE:8991937), complete cds.
BC132673 - Homo sapiens striatin, calmodulin binding protein 3, mRNA (cDNA clone MGC:164304 IMAGE:40146695), complete cds.
BC143933 - Homo sapiens cDNA clone IMAGE:9052451.
AK314041 - Homo sapiens cDNA, FLJ94701, highly similar to Homo sapiens striatin, calmodulin binding protein 3 (STRN3), mRNA.
KJ898757 - Synthetic construct Homo sapiens clone ccsbBroadEn_08151 STRN3 gene, encodes complete protein.
JD320354 - Sequence 301378 from Patent EP1572962.
JD044309 - Sequence 25333 from Patent EP1572962.
JD318971 - Sequence 299995 from Patent EP1572962.
JD489756 - Sequence 470780 from Patent EP1572962.
AF243424 - Homo sapiens SG2NA beta isoform mRNA, partial cds.
JD353713 - Sequence 334737 from Patent EP1572962.
JD495065 - Sequence 476089 from Patent EP1572962.
JD263788 - Sequence 244812 from Patent EP1572962.
JD219783 - Sequence 200807 from Patent EP1572962.
JD488310 - Sequence 469334 from Patent EP1572962.
JD195820 - Sequence 176844 from Patent EP1572962.
JD054954 - Sequence 35978 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RTX7, A6NHZ7, GS2NA, NM_001083893, NP_001077362, Q13033, Q9NRA5, SG2NA, STRN3_HUMAN
UCSC ID: uc001wqu.2
RefSeq Accession: NM_001083893
Protein: Q13033 (aka STRN3_HUMAN or STR3_HUMAN)
CCDS: CCDS41938.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001083893.1
exon count: 18CDS single in 3' UTR: no RNA size: 4233
ORF size: 2394CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4859.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.