Description: Homo sapiens chromosome 7 open reading frame 10 (SUGCT), transcript variant 3, mRNA. RefSeq Summary (NM_001193313): This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr7:40,174,575-40,900,366 Size: 725,792 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr7:40,174,599-40,900,078 Size: 725,480 Coding Exon Count: 14
ID:CG010_HUMAN DESCRIPTION: RecName: Full=CaiB/baiF CoA-transferase family protein C7orf10; EC=2.-.-.-; AltName: Full=Dermal papilla-derived protein 13; TISSUE SPECIFICITY: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined. DISEASE: Defects in C7orf10 are the cause of glutaric aciduria type 3 (GA3) [MIM:231690]. GA3 is a metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3- hydroxyglutaric acid. SIMILARITY: Belongs to the CaiB/BaiF CoA-transferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02515 - CoA-transferase family III
SCOP Domains: 89796 - CoA-transferase family III (CaiB/BaiF)
ModBase Predicted Comparative 3D Structure on Q9HAC7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.