Description: Homo sapiens TRAF family member-associated NFKB activator (TANK), transcript variant 1, mRNA. RefSeq Summary (NM_004180): The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr2:161,993,466-162,092,683 Size: 99,218 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr2:162,036,174-162,092,029 Size: 55,856 Coding Exon Count: 7
ID:TANK_HUMAN DESCRIPTION: RecName: Full=TRAF family member-associated NF-kappa-B activator; AltName: Full=TRAF-interacting protein; Short=I-TRAF; FUNCTION: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. SUBUNIT: Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. INTERACTION: O96018:APBA3; NbExp=2; IntAct=EBI-356349, EBI-6115839; P53350:PLK1; NbExp=3; IntAct=EBI-356349, EBI-476768; Q9UHD2:TBK1; NbExp=3; IntAct=EBI-356349, EBI-356402; Q12933:TRAF2; NbExp=3; IntAct=EBI-356349, EBI-355744; Q13114:TRAF3; NbExp=3; IntAct=EBI-356349, EBI-357631; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated by IKBKE. SIMILARITY: Contains 1 C2H2-type zinc finger.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92844
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-933537 Recruitment of TANK to TRAF6 R-HSA-5362486 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 R-HSA-9013985 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 R-HSA-933527 Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 R-HSA-936941 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation R-HSA-9013986 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation R-HSA-933538 Recruitment of IRF7 to TRAF6 R-HSA-933525 Phosphorylation and release of IRF7 R-HSA-166271 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 R-HSA-166245 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex R-HSA-9013979 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 R-HSA-9013978 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168249 Innate Immune System R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168256 Immune System R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade