Human Gene TAX1BP1 (uc003szl.3)
  Description: Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), transcript variant 1, mRNA.
RefSeq Summary (NM_006024): This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
Transcript (Including UTRs)
   Position: hg19 chr7:27,779,714-27,869,386 Size: 89,673 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr7:27,788,144-27,868,448 Size: 80,305 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:27,779,714-27,869,386)mRNA (may differ from genome)Protein (789 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer
GeneCardsGeneNetworkH-INVHGNCHPRDLynx
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TAXB1_HUMAN
DESCRIPTION: RecName: Full=Tax1-binding protein 1; AltName: Full=TRAF6-binding protein;
FUNCTION: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
SUBUNIT: Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.
INTERACTION: O15111:CHUK; NbExp=2; IntAct=EBI-529518, EBI-81249; Q9Y3M8:STARD13; NbExp=2; IntAct=EBI-529518, EBI-465487; Q9Y4K3:TRAF6; NbExp=3; IntAct=EBI-529518, EBI-359276;
TISSUE SPECIFICITY: Expressed in all tissues tested.
PTM: Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
SEQUENCE CAUTION: Sequence=AAC13359.2; Type=Erroneous gene model prediction;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TAX1BP1
CDC HuGE Published Literature: TAX1BP1

-  MalaCards Disease Associations
  MalaCards Gene Search: TAX1BP1
Diseases sorted by gene-association score: t-cell leukemia (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C032668 1-nitropyrene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane
  • C011269 2,5-hexanedione
  • C023514 2,6-dinitrotoluene
  • C075773 4-phenylbutyric acid
  • D000082 Acetaminophen
  • D016573 Agrochemicals
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.66 RPKM in Adrenal Gland
Total median expression: 1318.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.00182-0.368 Picture PostScript Text
3' UTR -205.85938-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012852 - CoCoA
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF07888 - Calcium binding and coiled-coil domain (CALCOCO1) like

ModBase Predicted Comparative 3D Structure on Q86VP1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0046872 metal ion binding

Biological Process:
GO:0006915 apoptotic process
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0043066 negative regulation of apoptotic process

Cellular Component:
GO:0005829 cytosol
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK299729 - Homo sapiens cDNA FLJ56149 complete cds, highly similar to Tax1-binding protein 1.
LF384111 - JP 2014500723-A/191614: Polycomb-Associated Non-Coding RNAs.
AK314292 - Homo sapiens cDNA, FLJ95049, Homo sapiens Tax1 (human T-cell leukemia virus type I) bindingprotein 1 (TAX1BP1), mRNA.
AK296720 - Homo sapiens cDNA FLJ52320 complete cds, highly similar to Tax1-binding protein 1.
BC024600 - Homo sapiens cDNA clone IMAGE:4339438, containing frame-shift errors.
AK301064 - Homo sapiens cDNA FLJ54388 complete cds, highly similar to Tax1-binding protein 1.
AF090891 - Homo sapiens clone HQ0105 PRO0105 mRNA, complete cds.
LP895568 - Sequence 432 from Patent EP3253886.
AK000098 - Homo sapiens cDNA FLJ20091 fis, clone COL04152, highly similar to U33821 Human tax1-binding protein TXBP151 mRNA.
AL136586 - Homo sapiens mRNA; cDNA DKFZp761B192 (from clone DKFZp761B192).
BC001764 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1, mRNA (cDNA clone IMAGE:3352710), **** WARNING: chimeric clone ****.
U33821 - Homo sapiens tax1-binding protein TXBP151 mRNA, complete cds.
BC050358 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1, mRNA (cDNA clone MGC:51743 IMAGE:6055189), complete cds.
MA619688 - JP 2018138019-A/191614: Polycomb-Associated Non-Coding RNAs.
JD399965 - Sequence 380989 from Patent EP1572962.
AM393835 - Synthetic construct Homo sapiens clone IMAGE:100001732 for hypothetical protein (TAX1BP1 gene).
CU690646 - Synthetic construct Homo sapiens gateway clone IMAGE:100021541 5' read TAX1BP1 mRNA.
CR457056 - Homo sapiens full open reading frame cDNA clone RZPDo834F0514D for gene TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1; complete cds, incl. stopcodon.
AB463302 - Synthetic construct DNA, clone: pF1KB8592, Homo sapiens TAX1BP1 gene for Tax binding protein 1, without stop codon, in Flexi system.
KJ897931 - Synthetic construct Homo sapiens clone ccsbBroadEn_07325 TAX1BP1 gene, encodes complete protein.
AF268075 - Homo sapiens TRAF6-binding protein T6BP mRNA, complete cds.
CR533556 - Homo sapiens full open reading frame cDNA clone RZPDo834F0621D for gene TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1; complete cds, incl. stopcodon.
LF362446 - JP 2014500723-A/169949: Polycomb-Associated Non-Coding RNAs.
LF362449 - JP 2014500723-A/169952: Polycomb-Associated Non-Coding RNAs.
LF362451 - JP 2014500723-A/169954: Polycomb-Associated Non-Coding RNAs.
LF362452 - JP 2014500723-A/169955: Polycomb-Associated Non-Coding RNAs.
LF362455 - JP 2014500723-A/169958: Polycomb-Associated Non-Coding RNAs.
AK309757 - Homo sapiens cDNA, FLJ99798.
LF362456 - JP 2014500723-A/169959: Polycomb-Associated Non-Coding RNAs.
LF362457 - JP 2014500723-A/169960: Polycomb-Associated Non-Coding RNAs.
LF362459 - JP 2014500723-A/169962: Polycomb-Associated Non-Coding RNAs.
LF362462 - JP 2014500723-A/169965: Polycomb-Associated Non-Coding RNAs.
JD026581 - Sequence 7605 from Patent EP1572962.
JD028658 - Sequence 9682 from Patent EP1572962.
LF362463 - JP 2014500723-A/169966: Polycomb-Associated Non-Coding RNAs.
JD056033 - Sequence 37057 from Patent EP1572962.
JD166409 - Sequence 147433 from Patent EP1572962.
JD563286 - Sequence 544310 from Patent EP1572962.
LF362464 - JP 2014500723-A/169967: Polycomb-Associated Non-Coding RNAs.
LF362465 - JP 2014500723-A/169968: Polycomb-Associated Non-Coding RNAs.
MA598023 - JP 2018138019-A/169949: Polycomb-Associated Non-Coding RNAs.
MA598026 - JP 2018138019-A/169952: Polycomb-Associated Non-Coding RNAs.
MA598028 - JP 2018138019-A/169954: Polycomb-Associated Non-Coding RNAs.
MA598029 - JP 2018138019-A/169955: Polycomb-Associated Non-Coding RNAs.
MA598032 - JP 2018138019-A/169958: Polycomb-Associated Non-Coding RNAs.
MA598033 - JP 2018138019-A/169959: Polycomb-Associated Non-Coding RNAs.
MA598034 - JP 2018138019-A/169960: Polycomb-Associated Non-Coding RNAs.
MA598036 - JP 2018138019-A/169962: Polycomb-Associated Non-Coding RNAs.
MA598039 - JP 2018138019-A/169965: Polycomb-Associated Non-Coding RNAs.
MA598040 - JP 2018138019-A/169966: Polycomb-Associated Non-Coding RNAs.
MA598041 - JP 2018138019-A/169967: Polycomb-Associated Non-Coding RNAs.
MA598042 - JP 2018138019-A/169968: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86VP1 (Reactome details) participates in the following event(s):

R-HSA-937337 TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
R-HSA-5693055 TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
R-HSA-5693108 TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-75893 TNF signaling
R-HSA-168249 Innate Immune System
R-HSA-73887 Death Receptor Signalling
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006024, NP_006015, O60398, O95770, PRO0105, Q13311, Q86VP1, Q9BQG5, Q9UI88, T6BP, TAXB1_HUMAN
UCSC ID: uc003szl.3
RefSeq Accession: NM_006024
Protein: Q86VP1 (aka TAXB1_HUMAN)
CCDS: CCDS5415.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006024.6
exon count: 17CDS single in 3' UTR: no RNA size: 3506
ORF size: 2370CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4910.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.