Description: Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), transcript variant 1, mRNA. RefSeq Summary (NM_006024): This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]. Transcript (Including UTRs) Position: hg19 chr7:27,779,714-27,869,386 Size: 89,673 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr7:27,788,144-27,868,448 Size: 80,305 Coding Exon Count: 16
ID:TAXB1_HUMAN DESCRIPTION: RecName: Full=Tax1-binding protein 1; AltName: Full=TRAF6-binding protein; FUNCTION: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. SUBUNIT: Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. INTERACTION: O15111:CHUK; NbExp=2; IntAct=EBI-529518, EBI-81249; Q9Y3M8:STARD13; NbExp=2; IntAct=EBI-529518, EBI-465487; Q9Y4K3:TRAF6; NbExp=3; IntAct=EBI-529518, EBI-359276; TISSUE SPECIFICITY: Expressed in all tissues tested. PTM: Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. SEQUENCE CAUTION: Sequence=AAC13359.2; Type=Erroneous gene model prediction;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TAX1BP1 CDC HuGE Published Literature: TAX1BP1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07888 - Calcium binding and coiled-coil domain (CALCOCO1) like
ModBase Predicted Comparative 3D Structure on Q86VP1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032480 negative regulation of type I interferon production GO:0043066 negative regulation of apoptotic process
US Server
