Human Gene TENM1 (uc010nqy.3)
  Description: Homo sapiens teneurin transmembrane protein 1 (TENM1), transcript variant 1, mRNA.
RefSeq Summary (NM_001163278): The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Transcript (Including UTRs)
   Position: hg19 chrX:123,509,756-124,097,666 Size: 587,911 Total Exon Count: 32 Strand: -
Coding Region
   Position: hg19 chrX:123,514,386-124,097,602 Size: 583,217 Coding Exon Count: 32 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:123,509,756-124,097,666)mRNA (may differ from genome)Protein (2732 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TENM1
Diseases sorted by gene-association score: anosmia, isolated congenital* (350), anal margin carcinoma (18), lacrimal gland carcinoma (9), lacrimal system cancer (8), lymphoproliferative syndrome, x-linked, 1 (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.40 RPKM in Brain - Cerebellum
Total median expression: 78.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.5064-0.133 Picture PostScript Text
3' UTR -1168.584630-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF06484 - Teneurin Intracellular Region
PF15636 - GHH signature containing HNH/Endo VII superfamily nuclease toxin

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q9UKZ4-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AF100772 - Homo sapiens tenascin-M1 (TNM1) mRNA, complete cds.
BC140783 - Homo sapiens odz, odd Oz/ten-m homolog 1(Drosophila), mRNA (cDNA clone MGC:176460 IMAGE:9021651), complete cds.
BC144542 - Homo sapiens cDNA clone IMAGE:9053069, containing frame-shift errors.
BC144543 - Homo sapiens odz, odd Oz/ten-m homolog 1(Drosophila), mRNA (cDNA clone MGC:178087 IMAGE:9053070), complete cds.
HE578281 - Homo sapiens partial mRNA for odz, odd Oz/ten-m homolog 1 (Drosophila) (ODZ1 gene), splice variant 1.
BC030766 - Homo sapiens cDNA clone IMAGE:4811759.
AK055765 - Homo sapiens cDNA FLJ31203 fis, clone KIDNE2003233.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001163278, NP_001156750, ODZ1, Q9UKZ4-2, TNM1
UCSC ID: uc010nqy.3
RefSeq Accession: NM_001163278
Protein: Q9UKZ4-2, splice isoform of Q9UKZ4 CCDS: CCDS14609.1, CCDS55488.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001163278.1
exon count: 32CDS single in 3' UTR: no RNA size: 12907
ORF size: 8199CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 16585.00frame shift in genome: no % Coverage: 99.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.