Human Gene TRA2A (uc003swi.3) Description and Page Index
Description: Homo sapiens transformer 2 alpha homolog (Drosophila) (TRA2A), mRNA. RefSeq Summary (NM_013293): This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr7:23,544,401-23,571,656 Size: 27,256 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr7:23,545,178-23,571,443 Size: 26,266 Coding Exon Count: 8
ID:TRA2A_HUMAN DESCRIPTION: RecName: Full=Transformer-2 protein homolog alpha; Short=TRA-2 alpha; Short=TRA2-alpha; AltName: Full=Transformer-2 protein homolog A; FUNCTION: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. SUBUNIT: Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated in the RS domains. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TRA2A CDC HuGE Published Literature: TRA2A Positive Disease Associations: Iron Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13595
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.