ID:CCD53_HUMAN DESCRIPTION: RecName: Full=WASH complex subunit CCDC53; AltName: Full=Coiled-coil domain-containing protein 53; FUNCTION: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. SUBUNIT: Component of the WASH complex, composed of F-actin- capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin- capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. INTERACTION: Q96EZ8:MCRS1; NbExp=3; IntAct=EBI-712969, EBI-348259; Q96AQ6:PBXIP1; NbExp=3; IntAct=EBI-712969, EBI-740845; SIMILARITY: Belongs to the CCDC53 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10152 - Subunit CCDC53 of WASH complex
ModBase Predicted Comparative 3D Structure on Q9Y3C0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.