Human Gene ZNF146 (uc010eeu.3)
  Description: Homo sapiens zinc finger protein 146 (ZNF146), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:36,705,504-36,729,675 Size: 24,172 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:36,727,343-36,728,221 Size: 879 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:36,705,504-36,729,675)mRNA (may differ from genome)Protein (292 aa)
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GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OZF_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein OZF; AltName: Full=Only zinc finger protein; AltName: Full=Zinc finger protein 146;
SUBUNIT: Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.
PTM: Sumoylated.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 10 C2H2-type zinc fingers.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OZFID267.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF146
CDC HuGE Published Literature: ZNF146
Positive Disease Associations: Arteries
Related Studies:
  1. Arteries
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.21 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 950.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -475.401449-0.328 Picture PostScript Text
3' UTR -354.391454-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q15072
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC065568 - Homo sapiens zinc finger protein 146, mRNA (cDNA clone IMAGE:6164356).
BC005154 - Homo sapiens cDNA clone IMAGE:3545849, containing frame-shift errors.
JD347863 - Sequence 328887 from Patent EP1572962.
X70394 - H.sapiens OZF mRNA.
JD550102 - Sequence 531126 from Patent EP1572962.
JD360701 - Sequence 341725 from Patent EP1572962.
JD160614 - Sequence 141638 from Patent EP1572962.
BC110500 - Homo sapiens zinc finger protein 146, mRNA (cDNA clone MGC:125660 IMAGE:40028224), complete cds.
BC110501 - Homo sapiens zinc finger protein 146, mRNA (cDNA clone MGC:125661 IMAGE:40028226), complete cds.
JD386180 - Sequence 367204 from Patent EP1572962.
JD299042 - Sequence 280066 from Patent EP1572962.
JD263697 - Sequence 244721 from Patent EP1572962.
JD019735 - Sequence 759 from Patent EP1572962.
JD034210 - Sequence 15234 from Patent EP1572962.
JD053871 - Sequence 34895 from Patent EP1572962.
AK313460 - Homo sapiens cDNA, FLJ94005.
JD285748 - Sequence 266772 from Patent EP1572962.
JD314898 - Sequence 295922 from Patent EP1572962.
JD314899 - Sequence 295923 from Patent EP1572962.
JD314900 - Sequence 295924 from Patent EP1572962.
JD088547 - Sequence 69571 from Patent EP1572962.
JD188439 - Sequence 169463 from Patent EP1572962.
AB464376 - Synthetic construct DNA, clone: pF1KB8283, Homo sapiens ZNF146 gene for zinc finger protein 146, without stop codon, in Flexi system.
KJ897772 - Synthetic construct Homo sapiens clone ccsbBroadEn_07166 ZNF146 gene, encodes complete protein.
AK311486 - Homo sapiens cDNA, FLJ18528.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD437678 - Sequence 418702 from Patent EP1572962.
JD263657 - Sequence 244681 from Patent EP1572962.
JD113116 - Sequence 94140 from Patent EP1572962.
JD328632 - Sequence 309656 from Patent EP1572962.
JD041920 - Sequence 22944 from Patent EP1572962.
JD469436 - Sequence 450460 from Patent EP1572962.
JD101285 - Sequence 82309 from Patent EP1572962.
JD516303 - Sequence 497327 from Patent EP1572962.
JD563770 - Sequence 544794 from Patent EP1572962.
JD184245 - Sequence 165269 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001099638, NP_009076, OZF, OZF_HUMAN, Q15072, Q2TB94
UCSC ID: uc010eeu.3
RefSeq Accession: NM_001099638
Protein: Q15072 (aka OZF_HUMAN)
CCDS: CCDS12492.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001099638.1
exon count: 3CDS single in 3' UTR: no RNA size: 3806
ORF size: 879CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1284.50frame shift in genome: no % Coverage: 99.37
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.