Description: Homo sapiens zinc finger protein 335 (ZNF335), mRNA. RefSeq Summary (NM_022095): The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:44,577,292-44,600,833 Size: 23,542 Total Exon Count: 28 Strand: - Coding Region Position: hg19 chr20:44,577,592-44,600,049 Size: 22,458 Coding Exon Count: 27
ID:ZN335_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 335; AltName: Full=NRC-interacting factor 1; Short=NIF-1; FUNCTION: Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6. SUBUNIT: Interacts with NCOA6, but not with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR and PPARA. Interacts with CNOT6. Directly interacts with RQCD1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Relatively high expression in the skeletal muscle, thymus, placenta and blood. Moderate expression in the colon, kidney and lung. Low expression in the small intestine, heart, liver and brain. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 13 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAB15379.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ZNF335 CDC HuGE Published Literature: ZNF335
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4Z2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0001701 in utero embryonic development GO:0002052 positive regulation of neuroblast proliferation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007420 brain development GO:0010468 regulation of gene expression GO:0021895 cerebral cortex neuron differentiation GO:0040029 regulation of gene expression, epigenetic GO:0048812 neuron projection morphogenesis GO:0048854 brain morphogenesis GO:0050671 positive regulation of lymphocyte proliferation GO:0050767 regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0051569 regulation of histone H3-K4 methylation GO:0080182 histone H3-K4 trimethylation
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