Human Gene ZNF335 (uc002xqw.3)
  Description: Homo sapiens zinc finger protein 335 (ZNF335), mRNA.
RefSeq Summary (NM_022095): The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr20:44,577,292-44,600,833 Size: 23,542 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr20:44,577,592-44,600,049 Size: 22,458 Coding Exon Count: 27 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:44,577,292-44,600,833)mRNA (may differ from genome)Protein (1342 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSCGAPEnsemblEntrez GeneExonPrimer

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 335; AltName: Full=NRC-interacting factor 1; Short=NIF-1;
FUNCTION: Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6.
SUBUNIT: Interacts with NCOA6, but not with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR and PPARA. Interacts with CNOT6. Directly interacts with RQCD1.
TISSUE SPECIFICITY: Relatively high expression in the skeletal muscle, thymus, placenta and blood. Moderate expression in the colon, kidney and lung. Low expression in the small intestine, heart, liver and brain.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAB15379.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF335
CDC HuGE Published Literature: ZNF335

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF335
Diseases sorted by gene-association score: microcephaly 10, primary, autosomal recessive* (1629), microcephaly (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.97 RPKM in Brain - Cerebellum
Total median expression: 342.56 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.90123-0.349 Picture PostScript Text
3' UTR -122.60300-0.409 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13909 - C2H2-type zinc-finger domain
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9H4Z2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0001701 in utero embryonic development
GO:0002052 positive regulation of neuroblast proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0010468 regulation of gene expression
GO:0021895 cerebral cortex neuron differentiation
GO:0040029 regulation of gene expression, epigenetic
GO:0048812 neuron projection morphogenesis
GO:0048854 brain morphogenesis
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050767 regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0051569 regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0035097 histone methyltransferase complex

-  Descriptions from all associated GenBank mRNAs
  AF395833 - Homo sapiens zinc-finger/leucine-zipper co-transducer NIF1 mRNA, complete cds.
AK026157 - Homo sapiens cDNA: FLJ22504 fis, clone HRC11430.
AK074214 - Homo sapiens cDNA FLJ23634 fis, clone CAS05322.
BC041331 - Homo sapiens zinc finger protein 335, mRNA (cDNA clone IMAGE:5285131), partial cds.
BC142981 - Homo sapiens cDNA clone IMAGE:8860417.
AK296989 - Homo sapiens cDNA FLJ56899 complete cds, highly similar to Zinc finger protein 335.
AK122963 - Homo sapiens cDNA FLJ16685 fis, clone TRACH2024293, moderately similar to Gallus gallus zinc finger protein (Fzf-1).
JD222507 - Sequence 203531 from Patent EP1572962.
JD331560 - Sequence 312584 from Patent EP1572962.
JD206955 - Sequence 187979 from Patent EP1572962.
JD378621 - Sequence 359645 from Patent EP1572962.
BC166679 - Synthetic construct Homo sapiens clone IMAGE:100066405, MGC:195542 zinc finger protein 335 (ZNF335) mRNA, encodes complete protein.
AK027358 - Homo sapiens cDNA FLJ14452 fis, clone HEMBB1001839, weakly similar to GASTRULA ZINC FINGER PROTEIN XLCGF42.1.
AK092485 - Homo sapiens cDNA FLJ35166 fis, clone PLACE6012297, highly similar to Novel C2H2 type zinc finger protein.
AX747567 - Sequence 1092 from Patent EP1308459.
AK054694 - Homo sapiens cDNA FLJ30132 fis, clone BRACE1000166.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DLG7, NM_022095, NP_071378, Q548D0, Q9H4Z2, Q9H684, ZN335_HUMAN
UCSC ID: uc002xqw.3
RefSeq Accession: NM_022095
Protein: Q9H4Z2 (aka ZN335_HUMAN or Z335_HUMAN)
CCDS: CCDS13389.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_022095.3
exon count: 28CDS single in 3' UTR: no RNA size: 4462
ORF size: 4029CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 8198.00frame shift in genome: no % Coverage: 99.78
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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