Description: Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB), mRNA. RefSeq Summary (NM_004402): Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr1:3,773,845-3,801,993 Size: 28,149 Total Exon Count: 7 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC048797 - Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), mRNA (cDNA clone MGC:51917 IMAGE:5204996), complete cds. BC032827 - Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), mRNA (cDNA clone IMAGE:4820856), complete cds. AB028911 - Homo sapiens DFF40 beta mRNA for DNA fragmentation factor 40 kDa subunit beta, complete cds. AB028912 - Homo sapiens DFF40 gamma mRNA for DNA fragmentation factor 40 kDa subunit gamma, complete cds. AB028913 - Homo sapiens DFF40 delta mRNA for DNA fragmentation factor 40 kDa subunit delta, complete cds. AF064019 - Homo sapiens DNA fragmentation factor 40 kDa subunit (DFF40) mRNA, complete cds. AK027141 - Homo sapiens cDNA: FLJ23488 fis, clone LNG00589, highly similar to AF064019 Homo sapiens DNA fragmentation factor 40 kDa subunit (DFF40) mRNA. AK303065 - Homo sapiens cDNA FLJ50316 complete cds, highly similar to DNA fragmentation factor subunit beta (EC 3.-.-.-). AK290877 - Homo sapiens cDNA FLJ76791 complete cds, highly similar to Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB), transcript variant 1, mRNA. JD477590 - Sequence 458614 from Patent EP1572962. AK309316 - Homo sapiens cDNA, FLJ99357. JD203623 - Sequence 184647 from Patent EP1572962. JD056255 - Sequence 37279 from Patent EP1572962. JD195113 - Sequence 176137 from Patent EP1572962. JD136841 - Sequence 117865 from Patent EP1572962. AF409060 - Homo sapiens DNA fragmentation factor B truncated form I (DFFB) mRNA, complete cds, alternatively spliced. AF409061 - Homo sapiens DNA fragmentation factor B truncated form II (DFFB) mRNA, complete cds, alternatively spliced. AF409062 - Homo sapiens DNA fragmentation factor B truncated form III (DFFB) mRNA, complete cds, alternatively spliced. KJ896701 - Synthetic construct Homo sapiens clone ccsbBroadEn_06095 DFFB gene, encodes complete protein. AB013918 - Homo sapiens mRNA for CAD, complete cds. AF039210 - Homo sapiens caspase-activated nuclease mRNA, complete cds. AY438267 - Homo sapiens c-truncated caspase-activated DNase mRNA, complete cds; aberrantly spliced. AY438268 - Homo sapiens c-truncated caspase-activated DNase mRNA, complete cds; aberrantly spliced. JD299069 - Sequence 280093 from Patent EP1572962. JD280607 - Sequence 261631 from Patent EP1572962. JD507789 - Sequence 488813 from Patent EP1572962. JD364357 - Sequence 345381 from Patent EP1572962. JD513924 - Sequence 494948 from Patent EP1572962. JD513925 - Sequence 494949 from Patent EP1572962. JD069743 - Sequence 50767 from Patent EP1572962. JD414835 - Sequence 395859 from Patent EP1572962. JD414840 - Sequence 395864 from Patent EP1572962. JD251849 - Sequence 232873 from Patent EP1572962. JD120572 - Sequence 101596 from Patent EP1572962. JD379687 - Sequence 360711 from Patent EP1572962. JD379688 - Sequence 360712 from Patent EP1572962. JD379690 - Sequence 360714 from Patent EP1572962. JD311821 - Sequence 292845 from Patent EP1572962. JD311822 - Sequence 292846 from Patent EP1572962. JD081619 - Sequence 62643 from Patent EP1572962. JD081618 - Sequence 62642 from Patent EP1572962. JD438367 - Sequence 419391 from Patent EP1572962. JD223659 - Sequence 204683 from Patent EP1572962. JD133766 - Sequence 114790 from Patent EP1572962. JD240979 - Sequence 222003 from Patent EP1572962. JD234567 - Sequence 215591 from Patent EP1572962. JD545744 - Sequence 526768 from Patent EP1572962. JD355717 - Sequence 336741 from Patent EP1572962. JD355958 - Sequence 336982 from Patent EP1572962. JD483266 - Sequence 464290 from Patent EP1572962. JD240899 - Sequence 221923 from Patent EP1572962. JD367253 - Sequence 348277 from Patent EP1572962. JD325954 - Sequence 306978 from Patent EP1572962. JD153342 - Sequence 134366 from Patent EP1572962. JD527726 - Sequence 508750 from Patent EP1572962. JD161705 - Sequence 142729 from Patent EP1572962. JD523542 - Sequence 504566 from Patent EP1572962. JD262073 - Sequence 243097 from Patent EP1572962. JD165226 - Sequence 146250 from Patent EP1572962. JD560950 - Sequence 541974 from Patent EP1572962. JD542913 - Sequence 523937 from Patent EP1572962. JD547760 - Sequence 528784 from Patent EP1572962. JD213062 - Sequence 194086 from Patent EP1572962. JD407504 - Sequence 388528 from Patent EP1572962. JD095289 - Sequence 76313 from Patent EP1572962. JD374566 - Sequence 355590 from Patent EP1572962. JD489243 - Sequence 470267 from Patent EP1572962. JD489244 - Sequence 470268 from Patent EP1572962. JD072220 - Sequence 53244 from Patent EP1572962. JD505144 - Sequence 486168 from Patent EP1572962. JD099343 - Sequence 80367 from Patent EP1572962. JD242577 - Sequence 223601 from Patent EP1572962. JD242576 - Sequence 223600 from Patent EP1572962. JD374853 - Sequence 355877 from Patent EP1572962. JD157399 - Sequence 138423 from Patent EP1572962. JD115949 - Sequence 96973 from Patent EP1572962. JD106917 - Sequence 87941 from Patent EP1572962. JD075193 - Sequence 56217 from Patent EP1572962. JD377503 - Sequence 358527 from Patent EP1572962. JD088199 - Sequence 69223 from Patent EP1572962. JD532121 - Sequence 513145 from Patent EP1572962. JD334502 - Sequence 315526 from Patent EP1572962. JD428181 - Sequence 409205 from Patent EP1572962. JD268667 - Sequence 249691 from Patent EP1572962. JD513119 - Sequence 494143 from Patent EP1572962. JD298698 - Sequence 279722 from Patent EP1572962. JD352875 - Sequence 333899 from Patent EP1572962. JD542205 - Sequence 523229 from Patent EP1572962. JD424818 - Sequence 405842 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04210 - Apoptosis
BioCarta from NCI Cancer Genome Anatomy Project h_setPathway - Granzyme A mediated Apoptosis Pathway h_caspasePathway - Caspase Cascade in Apoptosis h_mitochondriaPathway - Role of Mitochondria in Apoptotic Signaling h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors h_tnfr1Pathway - TNFR1 Signaling Pathway h_fasPathway - FAS signaling pathway ( CD95 ) h_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF