Description: Homo sapiens heat shock 27kDa protein family, member 7 (cardiovascular) (HSPB7), mRNA. RefSeq Summary (NM_014424): This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]. Transcript (Including UTRs) Position: hg19 chr1:16,340,523-16,346,089 Size: 5,567 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr1:16,342,075-16,345,964 Size: 3,890 Coding Exon Count: 4
ID:Q8N241_HUMAN DESCRIPTION: SubName: Full=Heat shock 27kDa protein family, member 7 (Cardiovascular); SubName: Full=Heat shock 27kDa protein family, member 7 (Cardiovascular), isoform CRA_c; SubName: Full=Heat shock protein beta-7; SubName: Full=cDNA FLJ34956 fis, clone NTONG2003158, highly similar to Heat shock 27kD protein family, member 7; SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N241
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.