Human Gene TMEM222 (uc001bnr.4)
  Description: Homo sapiens transmembrane protein 222 (TMEM222), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:27,648,636-27,662,891 Size: 14,256 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:27,648,689-27,661,957 Size: 13,269 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:27,648,636-27,662,891)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM222_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 222;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=CAB66618.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.18 RPKM in Prostate
Total median expression: 882.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.8053-0.374 Picture PostScript Text
3' UTR -410.50934-0.440 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008496 - DUF778

Pfam Domains:
PF05608 - Protein of unknown function (DUF778)

ModBase Predicted Comparative 3D Structure on Q9H0R3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK313110 - Homo sapiens cDNA, FLJ93595.
AK303821 - Homo sapiens cDNA FLJ56305 complete cds.
AL136683 - Homo sapiens mRNA; cDNA DKFZp564D0478 (from clone DKFZp564D0478).
BC011579 - Homo sapiens transmembrane protein 222, mRNA (cDNA clone IMAGE:4548544), partial cds.
BC090039 - Homo sapiens transmembrane protein 222, mRNA (cDNA clone MGC:111002 IMAGE:6181849), complete cds.
EU831513 - Synthetic construct Homo sapiens clone HAIB:100066542; DKFZo004B0718 chromosome 1 open reading frame 160 protein (C1orf160) gene, encodes complete protein.
KJ904908 - Synthetic construct Homo sapiens clone ccsbBroadEn_14302 TMEM222 gene, encodes complete protein.
EU831420 - Synthetic construct Homo sapiens clone HAIB:100066449; DKFZo008B0717 chromosome 1 open reading frame 160 protein (C1orf160) gene, encodes complete protein.
AF251699 - Homo sapiens hypothetical protein SB71 mRNA, complete cds.
AK222642 - Homo sapiens mRNA for hypothetical protein DKFZp564D0478 variant, clone: CBL02969.
AK307077 - Homo sapiens cDNA, FLJ97025.
JD271282 - Sequence 252306 from Patent EP1572962.
AK123218 - Homo sapiens cDNA FLJ41224 fis, clone BRAMY2030098.
AK095889 - Homo sapiens cDNA FLJ38570 fis, clone HCHON2006722.
JD396340 - Sequence 377364 from Patent EP1572962.
JD210155 - Sequence 191179 from Patent EP1572962.
JD114748 - Sequence 95772 from Patent EP1572962.
JD102628 - Sequence 83652 from Patent EP1572962.
JD424797 - Sequence 405821 from Patent EP1572962.
JD338840 - Sequence 319864 from Patent EP1572962.
JD189300 - Sequence 170324 from Patent EP1572962.
JD173179 - Sequence 154203 from Patent EP1572962.
JD066153 - Sequence 47177 from Patent EP1572962.
JD432795 - Sequence 413819 from Patent EP1572962.
JD198676 - Sequence 179700 from Patent EP1572962.
JD109771 - Sequence 90795 from Patent EP1572962.
JD507122 - Sequence 488146 from Patent EP1572962.
JD104444 - Sequence 85468 from Patent EP1572962.
JD478836 - Sequence 459860 from Patent EP1572962.
JD222808 - Sequence 203832 from Patent EP1572962.
JD451044 - Sequence 432068 from Patent EP1572962.
JD371499 - Sequence 352523 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C1orf160, D3DPL6, NM_032125, NP_115501, Q53HD8, Q5FVE9, Q9H0R3, TM222_HUMAN
UCSC ID: uc001bnr.4
RefSeq Accession: NM_032125
Protein: Q9H0R3 (aka TM222_HUMAN)
CCDS: CCDS297.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032125.2
exon count: 6CDS single in 3' UTR: no RNA size: 1629
ORF size: 627CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1182.00frame shift in genome: no % Coverage: 99.08
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.